CAJ | 학술논문

疼痛和抑郁症存在共病联系,两者之间可能存在共同的神经解剖机制及分子机制。近年来研究发现,中枢神经系统中的脑源性生长因子( brain-derived neurotrophic factor,BD-NF)在疼痛-抑郁共病过程中发挥重要作用,BDNF也逐渐成为疼痛及抑郁症的研究热点及治疗靶点。该文就BDNF参与疼痛-抑郁共病的机制及外周血BDNF在疼痛、抑郁症的诊治中的意义做论述。
동통화억욱증존재공병련계,량자지간가능존재공동적신경해부궤제급분자궤제。근년래연구발현,중추신경계통중적뇌원성생장인자( brain-derived neurotrophic factor,BD-NF)재동통-억욱공병과정중발휘중요작용,BDNF야축점성위동통급억욱증적연구열점급치료파점。해문취BDNF삼여동통-억욱공병적궤제급외주혈BDNF재동통、억욱증적진치중적의의주논술。
The comorbidity of pain and depression is common. Both disorders might share common neuroanatomical and molecu-lar mechanisms. Recent studies have found that the brain-de-rived neurotrophic factor( BDNF) ,which plays an important role in the process of pain-depression comorbidity, has gradually be-come a hot topic and target of treatment. The article mainly sum-marizes the mechanism underlying comorbid pain and depres-sion,as well as the significance of blood BDNF in diagnosis and treatment of pain and depression.