中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
1期
15-18
,共4页
高迁移率族蛋白 B1%肺损伤%慢性阻塞性肺病%哮喘%肺纤维化%肺癌%肺炎%肺动脉高压
高遷移率族蛋白 B1%肺損傷%慢性阻塞性肺病%哮喘%肺纖維化%肺癌%肺炎%肺動脈高壓
고천이솔족단백 B1%폐손상%만성조새성폐병%효천%폐섬유화%폐암%폐염%폐동맥고압
high-mobility group box 1%lung injury%chronic ob-structive pulmonary disease%asthma%pulmonary fibrosis%lung cancer%pneumonia%pulmonary hypertension
高迁移率族蛋白 B1( high-mobility group box 1, HMGB1)是一种保守的核蛋白,对维持核小体稳定、DNA重组、复制、修复及转录有重要作用。其可由坏死的细胞被动释放,或在适宜刺激下主动分泌至胞外。近年的研究显示：HMGB1信号的活化与肺损伤、肺纤维化、肺癌等肺部疾病的发展密切相关,而阻断HMGB1信号可抑制其病理进程,说明HMGB1的抑制对这类疾病有潜在治疗价值。该文就HMGB1在呼吸系统疾病中的作用及其机制作一综述,以期为上述疾病的诊断和治疗提供新的理论依据。
高遷移率族蛋白 B1( high-mobility group box 1, HMGB1)是一種保守的覈蛋白,對維持覈小體穩定、DNA重組、複製、脩複及轉錄有重要作用。其可由壞死的細胞被動釋放,或在適宜刺激下主動分泌至胞外。近年的研究顯示：HMGB1信號的活化與肺損傷、肺纖維化、肺癌等肺部疾病的髮展密切相關,而阻斷HMGB1信號可抑製其病理進程,說明HMGB1的抑製對這類疾病有潛在治療價值。該文就HMGB1在呼吸繫統疾病中的作用及其機製作一綜述,以期為上述疾病的診斷和治療提供新的理論依據。
고천이솔족단백 B1( high-mobility group box 1, HMGB1)시일충보수적핵단백,대유지핵소체은정、DNA중조、복제、수복급전록유중요작용。기가유배사적세포피동석방,혹재괄의자격하주동분비지포외。근년적연구현시：HMGB1신호적활화여폐손상、폐섬유화、폐암등폐부질병적발전밀절상관,이조단HMGB1신호가억제기병리진정,설명HMGB1적억제대저류질병유잠재치료개치。해문취HMGB1재호흡계통질병중적작용급기궤제작일종술,이기위상술질병적진단화치료제공신적이론의거。
High-mobility group box 1 ( HMGB1 ) is a conserva-tive nuclear protein and plays an essential role in maintaining nu-cleosome stability, DNA recombination, replication, repair and transcription. It can be passively released by necrotic cells or ac-tively secreted into extracellular under appropriate stimulus. Re-cent studies show that the activation of HMGB1 signaling is closely related to the progress of lung diseases including lung in-jury, pulmonary fibrosis and lung cancer, while blocking HMGB1 signaling inhibits the pathological process, indicating the therapeutic potential of HMGB1 inhibition in treating these diseases. This review summarizes the role and mechanisms of HMGB1 in such diseases, in order to provide novel evidence for the diagnosis and treatment.
