现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
1期
131-133,134
,共4页
王小平%胥冰%马晓军%晁旭%李哲
王小平%胥冰%馬曉軍%晁旭%李哲
왕소평%서빙%마효군%조욱%리철
热休克蛋白%肿瘤%免疫
熱休剋蛋白%腫瘤%免疫
열휴극단백%종류%면역
heat shock proteins%tumor%immunity
热休克蛋白( heat shock protein,HSP)是一类在生物进化中高度保守、广泛存在于原核及真核生物中的蛋白质。近年热休克蛋白在免疫中的作用已成为当前研究的热点之一。已证实其能与肿瘤细胞内多肽分子结合,通过抗原提呈细胞上的受体,将抗原肽传递给细胞毒T细胞诱导特异性抗肿瘤免疫应答。热休克蛋白肽复合物作为一种疫苗,在生物治疗方面拥有广阔的治疗前景,值得深入研究。
熱休剋蛋白( heat shock protein,HSP)是一類在生物進化中高度保守、廣汎存在于原覈及真覈生物中的蛋白質。近年熱休剋蛋白在免疫中的作用已成為噹前研究的熱點之一。已證實其能與腫瘤細胞內多肽分子結閤,通過抗原提呈細胞上的受體,將抗原肽傳遞給細胞毒T細胞誘導特異性抗腫瘤免疫應答。熱休剋蛋白肽複閤物作為一種疫苗,在生物治療方麵擁有廣闊的治療前景,值得深入研究。
열휴극단백( heat shock protein,HSP)시일류재생물진화중고도보수、엄범존재우원핵급진핵생물중적단백질。근년열휴극단백재면역중적작용이성위당전연구적열점지일。이증실기능여종류세포내다태분자결합,통과항원제정세포상적수체,장항원태전체급세포독T세포유도특이성항종류면역응답。열휴극단백태복합물작위일충역묘,재생물치료방면옹유엄활적치료전경,치득심입연구。
The heat shock protein( HSP)is a highly conserved group of cellular proteins and is up-regulated under stress conditions. It functions as molecular chaperone and biochemical regulator to mediate cell growth,apoptosis,pro-tein homeostasis and cellular targets of peptides. Aside from their response to heat shock and chemical or physical stress stimuli,HSPs have been reported to be over-expressed in a wide range of human tumors. It has been confirmed that heat shock proteins could combine with tumor peptides,present the antigen to the immune cells through lympho-cyte receptor and elicit specific anti-tumor immunity via CTLs. As novel vaccines,heat shock proteins have a wide therapeutic prospect in biotherapy.