CAJ | 학술논문

目的：探讨青年女性胃癌患者的术后病理特点及预后分析。方法：回顾性分析2006年5月至2012年12月我院收治的48例青年女性（小于或等于40岁）胃癌患者的临床资料，与同期60-69岁老年女性胃癌患者共149例的术后病理资料及生存时间进行比较。结果：青年女性胃癌患者占全部女性胃癌患者的8.4%，绝大多数行根治术，术后病理示肿瘤多侵犯胃体、胃窦及小弯侧，病理类型上以低分化腺癌及印戒细胞癌为主，Lauren′s分型中弥漫型居多，相比于老年女性胃癌患者组有明显统计学差异（ p<0.01）。另其脉管受侵、淋巴结转移率也较高。随访两组中III-IV期患者各15例，青年女性胃癌组中位生存时间11.8个月，相比于老年组中位生存期21.5个月，生存时间明显缩短（ p=0.035）。结论：相比于老年女性，青年女性胃癌恶性程度高、预后差。
목적：탐토청년녀성위암환자적술후병리특점급예후분석。방법：회고성분석2006년5월지2012년12월아원수치적48례청년녀성（소우혹등우40세）위암환자적림상자료，여동기60-69세노년녀성위암환자공149례적술후병리자료급생존시간진행비교。결과：청년녀성위암환자점전부녀성위암환자적8.4%，절대다수행근치술，술후병리시종류다침범위체、위두급소만측，병리류형상이저분화선암급인계세포암위주，Lauren′s분형중미만형거다，상비우노년녀성위암환자조유명현통계학차이（ p<0.01）。령기맥관수침、림파결전이솔야교고。수방량조중III-IV기환자각15례，청년녀성위암조중위생존시간11.8개월，상비우노년조중위생존기21.5개월，생존시간명현축단（ p=0.035）。결론：상비우노년녀성，청년녀성위암악성정도고、예후차。
Objective:To investigate the pathological characteristics and prognosis of young female patients with gastric cancer. Methods:Clinical data of 48 young female patients(≤40years)with gastric cancer from May,2006 to December,2012 in Nanjing Drum Tower Hospital were retrospectively collected and analyzed,along with the postoper-ative pathological data and survival time of 149 old female patients treated at the same time were served as compari-son. Results:Young female patients with gastric cancer accounted for 8. 4% of the all included female patients,in which the vast majority of patients received radical resection. In the cohort of young female patients,postoperative pathological examination showed that most lesion were located in gastric body,antrum and small curvature,and patho-logical types were commonly poorly differentiated adenocarcinoma and signet ring cell carcinoma. Moreover,Lauren′s type were mostly diffuse type in female patients.χ2 test showed a significant difference of the pathological pattern be-tween young and old female patients(p<0. 01). Furthermore,young female patients had a higher rate of vessel inva-sion and lymph node metastasis than old female patients. In life test,there were 15 patients with the stage III-IV gas-tric carcinoma in each cohort. In comparison,the median survival time of patients in young group and old group was 11. 8 months versus 21. 5 months(p=0. 035). Conclusion:Young female patients with gastric carcinoma have higher degree of malignancy and worse outcome,therefore this cohort should be early diagnosed and treated.