现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
1期
85-88
,共4页
王小林%马任远%魏英%马茂
王小林%馬任遠%魏英%馬茂
왕소림%마임원%위영%마무
乙酰肝素酶%环氧化酶-2%肾癌%血管生成
乙酰肝素酶%環氧化酶-2%腎癌%血管生成
을선간소매%배양화매-2%신암%혈관생성
Heparanase%cyclooxygenase-2%renal cell carcinoma( RCC)%angiogenesis
目的:探讨Heparanase、COX-2在肾癌中表达的相关性及与肿瘤血管生成的关系及意义。方法:采用免疫组化PV6000法检测54例肾癌和20例正常肾脏组织中Hpa、COX-2蛋白的表达,以CD34单克隆抗体进行微血管内皮染色,计算微血管密度,分析Hpa、COX-2在肾癌中表达的相关性以及与临床病理特征及微血管密度的关系。结果:Hpa、COX-2在肾癌中的表达均较正常肾脏组织明显增高( p<0.05)。Hpa的表达与肾癌的临床分期、肿瘤大小、远处转移有关( p<0.05),而与患者年龄、性别、肿瘤的分化程度无相关性( p
目的:探討Heparanase、COX-2在腎癌中錶達的相關性及與腫瘤血管生成的關繫及意義。方法:採用免疫組化PV6000法檢測54例腎癌和20例正常腎髒組織中Hpa、COX-2蛋白的錶達,以CD34單剋隆抗體進行微血管內皮染色,計算微血管密度,分析Hpa、COX-2在腎癌中錶達的相關性以及與臨床病理特徵及微血管密度的關繫。結果:Hpa、COX-2在腎癌中的錶達均較正常腎髒組織明顯增高( p<0.05)。Hpa的錶達與腎癌的臨床分期、腫瘤大小、遠處轉移有關( p<0.05),而與患者年齡、性彆、腫瘤的分化程度無相關性( p
목적:탐토Heparanase、COX-2재신암중표체적상관성급여종류혈관생성적관계급의의。방법:채용면역조화PV6000법검측54례신암화20례정상신장조직중Hpa、COX-2단백적표체,이CD34단극륭항체진행미혈관내피염색,계산미혈관밀도,분석Hpa、COX-2재신암중표체적상관성이급여림상병리특정급미혈관밀도적관계。결과:Hpa、COX-2재신암중적표체균교정상신장조직명현증고( p<0.05)。Hpa적표체여신암적림상분기、종류대소、원처전이유관( p<0.05),이여환자년령、성별、종류적분화정도무상관성( p
Objective:To investigate the expression parterns of Heparanase and COX-2 protein in renal cell car-cinoma and their correlations with tumor progression and angiogenesis. Methods:The expressions of Heparanase and COX-2 in 54 renal cell carcinoma and 20 normal renal tissues were assessed by immunohistochemistry and the corre-lation with clinicopathologic features and microvessel density. Results:The expression of Heparanase and COX -2 protein significantly increased in renal cell carcinoma compared with that in normal renal tissues(p<0. 05). The ex-pression of Heparanase protein was positively correlated to the clinical stages,tumor diameter and distant metastasis of RCC(p<0. 05). There were no associations between the expression of Heparanase and age,gender and differentiation (p>0. 05). The expression of COX-2 protein was positively correlated to the clinical stage,differentiation and dis-tant metastasis of RCC(p<0. 05). There were no associations between the expression of COX-2 protein and tumor diameter,age and gender. RCC specimens had higher MVD than normal renal tissues(p<0. 05). Patients who showed high MVD was significantly associated with Heparanase and COX-2 positive tumors(p<0. 05). Heparanase and COX-2 positive tumors had a significantly higher MVD compared with negative tumors(p<0. 05). Expression of Heparanase was significantly correlated with that of COX-2(p<0. 05). Conclusion:Heparanase and COX-2 may be involved in malignancy of RCC through promoting tumor angiogenesis. It may be prognostic factors and therapeutic target of RCC.