CAJ | 학술논문

目的：探讨乳腺癌患者术前血清纤维蛋白原水平（ plasma fibrinogen concentration，PFC）的临床意义。方法：收集165例接受乳腺癌改良根治性手术、术后病理确诊为乳腺癌、TNM分期、ER/PR及术前PFC资料完整的患者手术标本，免疫组化检测Ki67和p53的表达，分析术前PFC与患者临床病理因素、p53和Ki67之间的关系。结果：乳腺癌患者术前PFC与患者的年龄和淋巴结转移无关，但T2期患者PFC明显高于T1期患者（p=0.048）。PFC与PR及HER-2的表达无关，但是ER阴性患者术前PFC明显高于ER阳性患者（p=0.031）。p53突变型患者的术前PFC明显高于p53野生型患者（ p=0.016）。Ki67阳性患者术前PFC明显高于Ki67阴性患者（ p=0.003）。结论：乳腺癌患者术前PFC是患者体内肿瘤细胞增殖速率的生物标志物。
목적：탐토유선암환자술전혈청섬유단백원수평（ plasma fibrinogen concentration，PFC）적림상의의。방법：수집165례접수유선암개량근치성수술、술후병리학진위유선암、TNM분기、ER/PR급술전PFC자료완정적환자수술표본，면역조화검측Ki67화p53적표체，분석술전PFC여환자림상병리인소、p53화Ki67지간적관계。결과：유선암환자술전PFC여환자적년령화림파결전이무관，단T2기환자PFC명현고우T1기환자（p=0.048）。PFC여PR급HER-2적표체무관，단시ER음성환자술전PFC명현고우ER양성환자（p=0.031）。p53돌변형환자적술전PFC명현고우p53야생형환자（ p=0.016）。Ki67양성환자술전PFC명현고우Ki67음성환자（ p=0.003）。결론：유선암환자술전PFC시환자체내종류세포증식속솔적생물표지물。
Objective:To explore the clinical significance of the preoperative plasma fibrinogen concentration ( PFC)in breast cancer. Methods:Collected the clinical pathological features and preoperative PFC of 165 breast cancer patients. To detect the expression of p53 and Ki67 using immunohistochemical SP method. To explore the rela-tionship between PFC and clinical characters,Ki67 and p53. Results:The preoperative PFC had no significant correla-tion with age and lymph node metastasis. It was correlated with tumor size(p=0. 048). The T2 stage breast cancer had a higher preoperative PFC than T1 stage. The preoperative PFC had no significant correlation with the expression of PR and HER-2. However,ER positive breast cancer had higher preoperative PFC than ER negative(p=0. 031). The p53-mutation breast cancer had higher preoperative PFC than p53-wild(p=0. 016). The Ki67 positive breast cancer had higher preoperative PFC than the Ki67 negative(p=0. 003). Conclusion:Preoperative PFC was a bio-marker of cell proliferation rate in breast cancer.