CAJ | 학술논문

目的：考察妇净舒片对苯酚胶浆所致的阴道宫颈炎模型大鼠的影响。方法：切除大鼠双侧卵巢，注射苯甲酸雌二醇和氢化可的松注射液造成大鼠假动情期和全身免疫功能低下，每鼠阴道内注入苯酚胶浆建立大鼠阴道宫颈炎模型，将大鼠随机分为模型对照组、妇净舒片大、中、小剂量组和妇科千金片组和假手术组，连续给药8d ，取血测定白细胞数，计算阴道宫颈脏器指数并进行病理学检查。结果：与模型组比较，妇净舒片大、中、小剂量组可降低白细胞数，大、中剂量组使大鼠阴道宫颈脏器指数降低。大剂量组可降低阴道上皮组织增生和宫颈上皮组织溃疡鳞化程度、降低阴道、宫颈炎性浸润和降低阴道充血水肿，中剂量组可降低阴道充血水肿。结论：妇净舒片对阴道宫颈炎模型大鼠有一定改善作用。
목적：고찰부정서편대분분효장소치적음도궁경염모형대서적영향。방법：절제대서쌍측란소，주사분갑산자이순화경화가적송주사액조성대서가동정기화전신면역공능저하，매서음도내주입분분효장건립대서음도궁경염모형，장대서수궤분위모형대조조、부정서편대、중、소제량조화부과천금편조화가수술조，련속급약8d ，취혈측정백세포수，계산음도궁경장기지수병진행병이학검사。결과：여모형조비교，부정서편대、중、소제량조가강저백세포수，대、중제량조사대서음도궁경장기지수강저。대제량조가강저음도상피조직증생화궁경상피조직궤양린화정도、강저음도、궁경염성침윤화강저음도충혈수종，중제량조가강저음도충혈수종。결론：부정서편대음도궁경염모형대서유일정개선작용。
Objective:To investigate the effects of Fujingshu Tablet on chronic pelvic inflammation caused by phenol mucilage model in rats . METHOD :The two ovaries of the rats were cut out .Injection of estradiol benzoate in‐jection in rats caused by false estrus ,Injection of hydrocortisone injection in rats caused by low immune function .Using phenol mucilage thought vagina to establish the chronic pelvic inflammation model in rats ,rats were randomly divided into control group ,model control group ,large ,medium and small dose group of Fujingshu Tablet and Fukeqianjin Tablet group .Drugs were given eight days ,observe the white blood cell ,uterine and ovarian organ index ,pathological histology of uterus of rats .RESULTS :Compared with the model group ,the large ,medium and small dose group of Fujingshu Tablet could significantly reduce white blood cell ,The large dose group could decrease the vaginal epithelial tissue hyperplasia and cervical squamous epithelial tissue ulcer degree ,reduce the vagina ,the cervix inflammatory infiltrates and vaginal hypere‐mia and edema .The medium dose group could decrease the vaginal hyperemia edema .CONCLUSION :Fujingshu Tablet has the mproving effect of vaginitis and cervicitis caused by phenol mucilage model in rats .