CAJ | 학술논문

目的：观察姜黄素对2型糖尿病肾病（DN ）大鼠肾脏的保护作用。方法：雄性SD大鼠，除空白组外均给予高脂高糖饲料，50d后腹腔注射STZ 30mg／kg建立2型DN 大鼠模型，造模成功后，随机分为模型组、姜黄素低、高剂量组，给药30d ，称重、检测大鼠血糖及血清肌酐（CRE）和尿素氮（BUN）水平；取右肾做 HE染色，观察大鼠肾组织病理学变化。结果：姜黄素各剂量组可显著性增加大鼠的体重（ P＜0．05或 P＜0．01）；姜黄素高剂量组血糖显著降低（P＜0．01）；姜黄素低、高剂量组CRE和BUN值显著性降低（P＜0．05或 P＜0．01）；HE染色显示，与模型组比较，姜黄素低、高剂量组大鼠肾脏组织形态有显著性改善。结论：姜黄素可增加2型糖尿病肾病模型大鼠的体重，降低血糖、CRE和BUN ，改善模型大鼠肾脏病理损伤，有一定肾脏保护作用。
목적：관찰강황소대2형당뇨병신병（DN ）대서신장적보호작용。방법：웅성SD대서，제공백조외균급여고지고당사료，50d후복강주사STZ 30mg／kg건립2형DN 대서모형，조모성공후，수궤분위모형조、강황소저、고제량조，급약30d ，칭중、검측대서혈당급혈청기항（CRE）화뇨소담（BUN）수평；취우신주 HE염색，관찰대서신조직병이학변화。결과：강황소각제량조가현저성증가대서적체중（ P＜0．05혹 P＜0．01）；강황소고제량조혈당현저강저（P＜0．01）；강황소저、고제량조CRE화BUN치현저성강저（P＜0．05혹 P＜0．01）；HE염색현시，여모형조비교，강황소저、고제량조대서신장조직형태유현저성개선。결론：강황소가증가2형당뇨병신병모형대서적체중，강저혈당、CRE화BUN ，개선모형대서신장병리손상，유일정신장보호작용。
Objective:To observe the influence of curcumin on kidney protection in type 2 diabetic nephropathy (DN) .Methods:Male SD rats ,except the blank group ,and the rest were induced to be diabetic nephropathy (DN) via in‐jection of STZ with 30 mg/kg after feeding high fat and sugar for 50 days .Model rats were divided into 3 groups random‐ly :model group ,low dosage and high dosage of curcumin group .Medicine was given for 30 dates ,measuring weight once a week .To measure weight and detect rats blood glucose ,creatinine (CRE) and urea nitrogen (BUN) level in 31st day . After HE staining the right kidney ,observe the changes of renal histopathological .Results :Curcumin low and high dose group could significantly increase the weight of the rats (P<0 .05 or P<0 .01);curcumin low blood sugar ,high dose group significantly lower (P<0 .05 or P<0 .01) ,significantly lower serum levels of CRE (P<0 .05 or P<0 .01);curcu‐min high dose group of serum BUN level significantly lower (P<0 .01);HE dyed curcumin was low ,the high dose group compared with model group ,kidney tissue morphology have significant difference .Conclusion :Curcumin can increase body weight of type 2 diabetic nephropathy model rat ,reduce blood sugar ,serum level of BUN and CRE ,improve the model of rat kidney pathological damage ,on DN rats model of kidney has a protective effect .