CAJ | 학술논문

目的：探讨NPR‐A在非小细胞肺癌（NSCLC）中的表达及与非小细胞肺癌患者临床病理资料之间的关系。方法：应用免疫组化方法检测NPR‐A 在45例NSCLC患者组织中的表达情况，并分析 NPR‐A 表达情况与 NSCLC 患者临床病理资料之间的关系。结果：NPR‐A 在NSCLC中主要表达于细胞浆和细胞膜，偶见细胞核表达；在45例NSCLC组织中，共有29例高表达，阳性率为64．4％。NPR‐A的表达与NSCLC患者吸烟、病理分级、分期及淋巴结的转移相关（P＜0．05），而与其他临床病理资料之间未见明显相关（P＞0．05）。结论：NPR‐A 在NSCLC患者中的表达与患者吸烟、病理分级、分期及淋巴结转移相关，提示了其表达参与了NSCLC的发展、转移，在NSCLC发展过程中起促进或协同作用。
목적：탐토NPR‐A재비소세포폐암（NSCLC）중적표체급여비소세포폐암환자림상병리자료지간적관계。방법：응용면역조화방법검측NPR‐A 재45례NSCLC환자조직중적표체정황，병분석 NPR‐A 표체정황여 NSCLC 환자림상병리자료지간적관계。결과：NPR‐A 재NSCLC중주요표체우세포장화세포막，우견세포핵표체；재45례NSCLC조직중，공유29례고표체，양성솔위64．4％。NPR‐A적표체여NSCLC환자흡연、병리분급、분기급림파결적전이상관（P＜0．05），이여기타림상병리자료지간미견명현상관（P＞0．05）。결론：NPR‐A 재NSCLC환자중적표체여환자흡연、병리분급、분기급림파결전이상관，제시료기표체삼여료NSCLC적발전、전이，재NSCLC발전과정중기촉진혹협동작용。
Objective:To investigate the expression of NPR‐A in non‐small cell lung cancer(NSCLC) tis‐sues and analyze the correlation with clinicopathological features .Methods:The expression of NPR‐A in 45 NSCLC tissues were measured by immunohistochemistry .The relationship between the expression of NPR‐A and clinico‐pathological features were analyzed .Results :NPR‐A is maily expressed in cytoplasm and membrane ,very few in nucleus .The positive rate of NPR‐A was 64 .4% in NSCLC .There was a significant relationship between expression status of NPR‐A and smoking ,differention ,staging or metastasis of lymph nodes (P<0 .05) .There was no corre‐lation between expression status of NPR‐A and sex or alcohol consumption (P>0 .05) .Conclusion:The expression of NPR‐A in NSCLC is unclear ,our study show that there was a significant relationship between expression status of NPR‐A and smoking ,differention ,staging or metastasis of lymph nodes ,which indicate its expression takes part in the tumorigenesis of NSCLC .