宁夏医学杂志
寧夏醫學雜誌
저하의학잡지
NINGXIA MEDICAL JOURNAL
2015年
1期
36-38
,共3页
张萍%顾洁%包生武%陈龙
張萍%顧潔%包生武%陳龍
장평%고길%포생무%진룡
人乳头瘤病毒%宫颈病变%宫颈癌
人乳頭瘤病毒%宮頸病變%宮頸癌
인유두류병독%궁경병변%궁경암
Human papilloma virus%Cervical lesions%Cervical cancer
目的：了解不同程度宫颈病变患者感染人乳头瘤病毒（ HPV）基因型分布的特征，探讨不同HPV型的致癌性。方法采用凯普医用核酸分子快速导流杂交基因芯片技术（ Hybrinax）对2884例银川地区女性进行生殖道21种HPV感染分型筛查，其中798例经阴道镜下多点活检，病理诊断分为宫颈炎症500例、CIN I 97例、CIN II 81例、CIN III 76例、宫颈癌44例，分析HPV感染基因型与宫颈病变程度的关系。结果2884例女性中HPV感染阳性率37．14％，宫颈病变中 HPV 感染阳性率89．22％，其中 CIN I 组阳性率为90．78％， CIN II 组阳性率96．30％，CIN III组阳性率97．37％，宫颈癌组阳性率100％，差异有统计学意义（P＜0．05）；CIN病变常见基因型为HPV16、58、18、52、31、33、35型，宫颈癌组中常见基因型依次为HPV16、18、58型，HPV16型在所有宫颈病变中均居首位。结论宫颈癌组中主要感染的HPV基因型符合中国人群研究结果，同时也有地域差异；HPV16、18、58型的致癌性较强，感染可增加宫颈癌的发生率。
目的：瞭解不同程度宮頸病變患者感染人乳頭瘤病毒（ HPV）基因型分佈的特徵，探討不同HPV型的緻癌性。方法採用凱普醫用覈痠分子快速導流雜交基因芯片技術（ Hybrinax）對2884例銀川地區女性進行生殖道21種HPV感染分型篩查，其中798例經陰道鏡下多點活檢，病理診斷分為宮頸炎癥500例、CIN I 97例、CIN II 81例、CIN III 76例、宮頸癌44例，分析HPV感染基因型與宮頸病變程度的關繫。結果2884例女性中HPV感染暘性率37．14％，宮頸病變中 HPV 感染暘性率89．22％，其中 CIN I 組暘性率為90．78％， CIN II 組暘性率96．30％，CIN III組暘性率97．37％，宮頸癌組暘性率100％，差異有統計學意義（P＜0．05）；CIN病變常見基因型為HPV16、58、18、52、31、33、35型，宮頸癌組中常見基因型依次為HPV16、18、58型，HPV16型在所有宮頸病變中均居首位。結論宮頸癌組中主要感染的HPV基因型符閤中國人群研究結果，同時也有地域差異；HPV16、18、58型的緻癌性較彊，感染可增加宮頸癌的髮生率。
목적：료해불동정도궁경병변환자감염인유두류병독（ HPV）기인형분포적특정，탐토불동HPV형적치암성。방법채용개보의용핵산분자쾌속도류잡교기인심편기술（ Hybrinax）대2884례은천지구녀성진행생식도21충HPV감염분형사사，기중798례경음도경하다점활검，병리진단분위궁경염증500례、CIN I 97례、CIN II 81례、CIN III 76례、궁경암44례，분석HPV감염기인형여궁경병변정도적관계。결과2884례녀성중HPV감염양성솔37．14％，궁경병변중 HPV 감염양성솔89．22％，기중 CIN I 조양성솔위90．78％， CIN II 조양성솔96．30％，CIN III조양성솔97．37％，궁경암조양성솔100％，차이유통계학의의（P＜0．05）；CIN병변상견기인형위HPV16、58、18、52、31、33、35형，궁경암조중상견기인형의차위HPV16、18、58형，HPV16형재소유궁경병변중균거수위。결론궁경암조중주요감염적HPV기인형부합중국인군연구결과，동시야유지역차이；HPV16、18、58형적치암성교강，감염가증가궁경암적발생솔。
Objective To understand the genotypes of human papilloma virus ( HPV) infection in patients with varying degrees of cervical lesions,and to explore the carcinogenicity of different HPV subtypes. Methods Using flow-throw hybridization and gene chip technology ( HybriMax) ,21 subtypes of HPV in female reproductive tract from 2 884 female patients were detected. The connection between HPV infection genotypes and degree of cervical lesion was investigated. Results Among 2 884 women screened,the HPV-pos?itive rate was 37. 14%. The HPV-positive rate was 89. 22% among those with cervical lesions. The CIN I positive rate was 90. 78%, CIN II positive 96. 30%,CIN III positive 97. 37%,and cervical cancer rate was 100% among all screened women (P<0. 05). The com?mon genotypes among CIN lesions were HPV16,58,18,52,31,33,and 35. The HPV 16,18,58 were found common among those with cervical cancer. HPV16 was ranked highest among those with cervical lesions. Conclusion The main HPV infection genotypes among those with cervical cancer are in line with Chinese population. HPV16,18,58 subtypes show rather strong carcinogenicity,and they can increase the incidence of cervical cancer. The HPV16 infection is the biggest threat of developing cervical cancer.
