CAJ | 학술논문

目的：观察超微脂康饮对实验性非酒精性脂肪肝（NAFLD）大鼠模型的疗效。方法 SD大鼠高脂饮食饲养6周后诱导非酒精性脂肪肝大鼠模型，肝脏病理切片证实造模成功；造模大鼠50只随机分为5组，超微脂康饮（低、中、高剂量）组给予相应剂量的超微脂康饮灌胃，壳脂胶囊组给予壳脂胶囊混悬液，模型组及空白组灌服蒸馏水，除空白组外，其余组仍予高脂饮食。6周后分别检测各组的肝功能、血脂、肝脂及肝脏组织学改变。各组之间比较采用单因素方差分析。结果超微脂康饮各组血清ALT、AST、肝组织脂质（TC、TG）等方面均优于模型组，差异均有统计学意义（P值均＜0．05），超微脂康饮中，低剂量组血清TG、TC显著优于模型组，差异均有统计学意义（P值均＜0.05）；超微脂康饮各组血清ALT、AST、肝组织TC与壳脂胶囊组比差差异无统计学意义（P值均＞0.05）。模型组及超微脂康饮各组均存在不同程度的肝脏炎症活动度，但与模型组比较，超微脂康饮各组、壳脂胶囊组大鼠的肝脏炎症活动度均有不同程度的改善（P值均＜0．05），而壳脂胶囊组较超微脂康饮各组改善稍明显（P值均＜0．05）。结论超微脂康饮能改善NAFLD大鼠肝功能、降低血脂、抑制肝脏炎症，整体疗效与壳脂胶囊相当，对非酒精性脂肪肝具有一定疗效。
목적：관찰초미지강음대실험성비주정성지방간（NAFLD）대서모형적료효。방법 SD대서고지음식사양6주후유도비주정성지방간대서모형，간장병리절편증실조모성공；조모대서50지수궤분위5조，초미지강음（저、중、고제량）조급여상응제량적초미지강음관위，각지효낭조급여각지효낭혼현액，모형조급공백조관복증류수，제공백조외，기여조잉여고지음식。6주후분별검측각조적간공능、혈지、간지급간장조직학개변。각조지간비교채용단인소방차분석。결과초미지강음각조혈청ALT、AST、간조직지질（TC、TG）등방면균우우모형조，차이균유통계학의의（P치균＜0．05），초미지강음중，저제량조혈청TG、TC현저우우모형조，차이균유통계학의의（P치균＜0.05）；초미지강음각조혈청ALT、AST、간조직TC여각지효낭조비차차이무통계학의의（P치균＞0.05）。모형조급초미지강음각조균존재불동정도적간장염증활동도，단여모형조비교，초미지강음각조、각지효낭조대서적간장염증활동도균유불동정도적개선（P치균＜0．05），이각지효낭조교초미지강음각조개선초명현（P치균＜0．05）。결론초미지강음능개선NAFLD대서간공능、강저혈지、억제간장염증，정체료효여각지효낭상당，대비주정성지방간구유일정료효。
Objective To observe the efficacy of Chaowei Zhikangyin in the treatment of the rat model of non-alcoholic fatty liver disease (NAFLD).Methods A rat model of NAFLD was established by feeding 50 Sprague-Dawley rats with high-fat diet for 6 weeks and was confirmed by liver pathological examination.Then,the model rats were randomly divided into five groups:low-,medium-,and high-dose Chaowei Zhikangyin groups (given Chaowei Zhikangyin by gavage),Kezhi capsule treatment group (given a suspension of Kezhi cap-sules),and model group (orally given distilled water).In addition,control rats were fed with normal diet and then treated with distilled wa-ter.Six weeks later,the liver function,blood lipids,liver lipids,and liver histology were examined.Results All Chaowei Zhikangyin groups were superior to the model group in terms of alanine aminotransferase,aspartate aminotransferase,total cholesterol (TC),and tri-glyceride (TG)in serum and TC and TG in liver tissues (P<0.05),but there were no significant differences between these Chaowei Zhi-kangyin groups and Kezhi capsule treatment group (P>0.05).Different degrees of liver inflammation was observed in the model group and Chaowei Zhikangyin groups;however,the Chaowei Zhikangyin groups and Kezhi capsule treatment group had reduced liver inflammation compared with the model group (P<0.05),and the Kezhi capsule treatment group showed a significantly more improvement than these Cha-owei Zhikangyin groups (P<0.05).Conclusion Chaowei Zhikangyin can improve liver function,reduce blood lipids,and inhibit liver in-flammation in rats with NAFLD,and it has comparable efficacy to Kezhi capsules.This therapy can be used for treating NAFLD.