CAJ | 학술논문

近年来肝纤维化的无创性诊断技术和方法日益受到重视，介绍了血清标志物、瞬时弹性成像技术（FibroScan）等非创伤性诊断技术在肝纤维诊断中的应用。抗肝纤维化治疗应是包括病因治疗、抗炎保肝、抑制细胞外基质合成和降解过多沉积的细胞外基质为一体的系统治疗。对于慢性病毒性肝炎所致的肝纤维化，抗病毒治疗是抗肝纤维化的基础，而中医药在抑制合成及降解过多沉积的以胶原为主的细胞外基质方面，具有作用于多个环节、多个层次和多个靶点的特性，而成为肝纤维化治疗的新希望。但是，中西医结合抗肝纤维化的优势仍需通过设计严谨、多中心、大样本的临床研究以提供循证医学证据支持，而深入研究中医药抗肝纤维化作用机制也是今后的重要任务之一。
근년래간섬유화적무창성진단기술화방법일익수도중시，개소료혈청표지물、순시탄성성상기술（FibroScan）등비창상성진단기술재간섬유진단중적응용。항간섬유화치료응시포괄병인치료、항염보간、억제세포외기질합성화강해과다침적적세포외기질위일체적계통치료。대우만성병독성간염소치적간섬유화，항병독치료시항간섬유화적기출，이중의약재억제합성급강해과다침적적이효원위주적세포외기질방면，구유작용우다개배절、다개층차화다개파점적특성，이성위간섬유화치료적신희망。단시，중서의결합항간섬유화적우세잉수통과설계엄근、다중심、대양본적림상연구이제공순증의학증거지지，이심입연구중의약항간섬유화작용궤제야시금후적중요임무지일。
In recent years,non-invasive methods for assessment of hepatic fibrosis have attracted more and more attention,and the appli-cation of non-invasive diagnostic techniques such as serum markers and transient elastography (FibroScan)for hepatic fibrosis is reviewed. Anti-fibrosis treatments should integrate etiological treatment,anti-inflammatory and liver-protecting therapy,and inhibiting the synthe-sis of extracellular matrix and degrading excessively deposited extracellular matrix.Antiviral treatment is the basis for resisting hepatic fibro-sis due to chronic viral hepatitis.In this aspect,traditional Chinese medicine (TCM)has advantages in inhibiting the synthesis of extracellu-lar matrix and degrading excessively deposited extracellular matrix,because it effects on multiple links,at multiple levels,and against multi-ple targets.So integrated traditional Chinese and Western medicine therapy is a promising treatment strategy.However,the benefit of inte-grative therapy against hepatic fibrosis still needs to be supported by rigorously designed,multicenter,large-sample clinical studies,and the mechanism of anti-fibrosis TCM treatment deserves further studies.