CAJ | 학술논문

目的：探讨低密度脂蛋白胆固醇(LDL-C) Friedewald计算法(F法)与均相法的结果相关性。方法调取进行血脂检测[包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]的984例空腹标本的检测数据，按TG水平分组比较F法与均相法所得LDL-C的相关性及其对血脂水平风险评估的影响。结果两法所得LDL-C的相关性均良好(R≥0.817)，两法所得LDL-C的差异无统计学意义(P>0.05)。随着TG升高，两种方法血脂水平分级的一致性降低。结论 F法计算LDL-C适用于多数人群(无乳糜，TG<4.52 mmol/L)血脂水平的评价；F法的准确使用需严格排除Ⅲ型及继发性高脂蛋白血症。
목적：탐토저밀도지단백담고순(LDL-C) Friedewald계산법(F법)여균상법적결과상관성。방법조취진행혈지검측[포괄총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)]적984례공복표본적검측수거，안TG수평분조비교F법여균상법소득LDL-C적상관성급기대혈지수평풍험평고적영향。결과량법소득LDL-C적상관성균량호(R≥0.817)，량법소득LDL-C적차이무통계학의의(P>0.05)。수착TG승고，량충방법혈지수평분급적일치성강저。결론 F법계산LDL-C괄용우다수인군(무유미，TG<4.52 mmol/L)혈지수평적평개；F법적준학사용수엄격배제Ⅲ형급계발성고지단백혈증。
Objective To compare the low-density lipoprotein cholesterol (LDL-C) concentrations measured by a direct homogeneous assay and by the Friedewald formula. Methods A total of 984 routine samples with triglyc-eride (TG) concentrations<4.52 mmol/L were enrolled for blood lipids examination, including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), LDL-C. LDL-C were measured by both enzymatic homogeneous assay (LDL-C(D)) and Friedewald formula (LDL-C(F)). Correlation and linear regression analysis were performed, and the concordance of the National Cholesterol Education Program (NCEP) risk category was estimated by paired-samples t test. Results Correlation between LDL-C(D) and LDL-C(F) was quite good (R≥0.817). The dif-ference between LDL-C(F) and LDL-C(D) was not statistically significant (P>0.05). The concordance between LDL-C (F) and LDL-C (D) declined as TG increased. Conclusion Friedewald formula is valid for the estimation of most TG<4.52 mmol/L specimen without chyle.Patients with type Ⅲ or secondary hyperlipoproteinemia should be screened to ensure the accuracy of Friedewald method.