CAJ | 학술논문

目的：研究三叉神经痛(TN)大鼠时其三叉神经节(TG)内谷氨酸(Glu)表达与分布的关系。方法皮下注射硝酸甘油构建三叉神经痛大鼠模型；应用免疫组化技术检测大鼠三叉神经节Glu含量与分布。结果皮下注射硝酸甘油构建三叉神经痛大鼠的三叉神经节内Glu含量增多且其主要分布在三叉神经节表层。结论 Glu可能与三叉神经痛发生有密切关系。
목적：연구삼차신경통(TN)대서시기삼차신경절(TG)내곡안산(Glu)표체여분포적관계。방법피하주사초산감유구건삼차신경통대서모형；응용면역조화기술검측대서삼차신경절Glu함량여분포。결과피하주사초산감유구건삼차신경통대서적삼차신경절내Glu함량증다차기주요분포재삼차신경절표층。결론 Glu가능여삼차신경통발생유밀절관계。
Objective To study the distribution of glutamate (Glu) expression within the trigeminal ganglia (TG) in rats with trigeminal neuralgia (TN). Methods Rats models with TG were constructed by subcutaneous injec-tion of nitroglycerin trigeminal neuralgia. Immunohistochemical technique was applied to detect the contents and dis-tribution of Glu. Results The level of glutamic acid was found increased in trigeminal ganglion in the rat models, and it was mainly distributed in the surface layer of trigeminal ganglion. Conclusion Glu may have close relation-ship with TN.