CAJ | 학술논문

目的：分析研究质子泵抑制剂不良反应的相关因素。方法：通过查阅国内外相关文献资料的形式，来进行质子泵抑制剂致不良反应相关因素的分析。并将随机抽取2012年5月～2014年3月到广东某医院就诊的100例消化性溃疡病患者作为研究对象，随机分为观察组（n=50）和对照组（n=50）；给予对照组患者雷尼替丁治疗，给予观察组患者奥美拉唑治疗；比较两组患者不良反应的发生率以及治疗效果。结果：质子泵会对身体各个器官或组织造成不同程度的伤害，甚至会出现严重不良反应的情况；观察组患者的不良反应发生率明显高于对照组，组间比较差异具有统计学意义P＜0.05；观察组患者的治疗有效率明显高于对照组，组间比较差异具有统计学意义P＜0.05。结论：质子泵抑制剂虽治疗效果显著，但引发患者出现药品不良反应的几率较高，因此要不断加大对于质子泵抑制剂的使用安全性以及可能发生的不良反应情况的观察研究力度。
목적：분석연구질자빙억제제불량반응적상관인소。방법：통과사열국내외상관문헌자료적형식，래진행질자빙억제제치불량반응상관인소적분석。병장수궤추취2012년5월～2014년3월도엄동모의원취진적100례소화성궤양병환자작위연구대상，수궤분위관찰조（n=50）화대조조（n=50）；급여대조조환자뢰니체정치료，급여관찰조환자오미랍서치료；비교량조환자불량반응적발생솔이급치료효과。결과：질자빙회대신체각개기관혹조직조성불동정도적상해，심지회출현엄중불량반응적정황；관찰조환자적불량반응발생솔명현고우대조조，조간비교차이구유통계학의의P＜0.05；관찰조환자적치료유효솔명현고우대조조，조간비교차이구유통계학의의P＜0.05。결론：질자빙억제제수치료효과현저，단인발환자출현약품불량반응적궤솔교고，인차요불단가대대우질자빙억제제적사용안전성이급가능발생적불량반응정황적관찰연구력도。
Objective:Analysis of proton pump inhibitors adverse reactions related factors.Methods:After a review of relevant literature in the form of domestic and foreign, to analysis of proton pump inhibitors cause adverse reactions related factors.And randomly selected in May 2012~March 2014 to a hospital for treatment of 100 cases of peptic ulcer Guangdong patients as research subjects,Were randomly divided into two groups(n=50)and control group(n=50);Ranitidine treatment given to patients in the control group;Given omeprazole-treated patients in the observation group;Probability of occurrence and treatment of patients with adverse reactions were compared. Results:Proton pump various body organs or tissues will cause varying degrees of damage, there may even be serious adverse reactions;Adverse reactions observed in patients was significantly higher probability of occurrence, the differences between the two groups was statistically significant P<0.05;Treatment of patients in the observation group was significantly higher efficiency, the difference between groups was statistically significant P<0.05;Conclusions:Although proton pump inhibitor therapy effect is remarkable, but the probability of adverse drug reactions in patients with raised higher, so to continue to increase the use of proton pump inhibitors for safety and adverse reactions may occur observation research efforts.