CAJ | 학술논문

目的：观察咪康唑莫米松皮肤成膜凝胶的体外透皮性能。方法：采用HPLC-DAD法测定咪康唑莫米松的含量，用Franz扩散池以离体鼠皮为透皮屏障进行体外透皮扩散试验，并计算咪康唑莫米松药物累积透皮量Q（Q 咪和Q 莫）和透皮速率常数J（J 咪和J 莫）。结果：咪康唑与莫米松的色谱峰能有效分离，进样量分别在1.0～400.0μg·ml-1和0.1～40.0μg·ml-1范围与各自峰面积呈良好线性关系，r值分别为0.9988和0.9982（n=6），咪康唑与莫米松的J值分别为（17.810±0.558）μg·cm-2和（1.821±0.941）μg·cm-2·h-1，r值分别为0.9913和0.9908，无显著差异（P≥0.05），咪康唑莫米松的透皮吸收行为均符合零级动力学方程。结论：咪康唑莫米松皮肤成膜凝胶，可开发为经皮给药制剂。
목적：관찰미강서막미송피부성막응효적체외투피성능。방법：채용HPLC-DAD법측정미강서막미송적함량，용Franz확산지이리체서피위투피병장진행체외투피확산시험，병계산미강서막미송약물루적투피량Q（Q 미화Q 막）화투피속솔상수J（J 미화J 막）。결과：미강서여막미송적색보봉능유효분리，진양량분별재1.0～400.0μg·ml-1화0.1～40.0μg·ml-1범위여각자봉면적정량호선성관계，r치분별위0.9988화0.9982（n=6），미강서여막미송적J치분별위（17.810±0.558）μg·cm-2화（1.821±0.941）μg·cm-2·h-1，r치분별위0.9913화0.9908，무현저차이（P≥0.05），미강서막미송적투피흡수행위균부합령급동역학방정。결론：미강서막미송피부성막응효，가개발위경피급약제제。
Objective To observe the performance of in vitro transdermal permeability of miconazole/mometasone skin membrane gel. Methods The quantity of miconazole and mometasone was measured by the method of HPLC-DAD. In vitro transdermal diffusion experiment was carried out by Franz diffusion cell with excised rat skin as the transdermal barrier. The accumulative quantity of transdermal delivery of miconazole and mometasone Q (Q miconazole and Q mometasone)and the transdermal speed constant J (J miconazole and J mometasone)were calculated. Results The chromatographic peak of miconazole could be effectively separated from that of mometasone. The injection volumes of miconazole and mometasone were respectively in the ranges of 1.0~400.0μg·ml-1(r=0.9988)and 0.1~40.0μg·ml-1(r=0.9982)(n=6), which had good linear relationship with their respective peak areas. The values of J miconazole and J mometasone were respectively (17.810±0.558)μg·cm-2, h-1 (r=0.9913)and (1.821±0.941)μg·cm-2,h-1 (r=0.9908),while there was no significant difference between these two values (P≥0.05). The transdermal absorption of miconazole and mometasone were in compliance with the zero-grade kinetics equation. Conclusion The miconazole/mometasone skin membrane gel could be developed as the transdermal delivery agent.