CAJ | 학술논문

目的：建立以紫外分光光度法测定阿替洛尔缓释微囊含量的方法。方法：将阿替洛尔缓释微囊研磨破碎，转移至容量瓶中，稀释后，在224nm处进行含量测定。结果：阿替洛尔在224nm处有最大吸收，辅料对测定无干扰。标准曲线方程：A=0.0355C+0.0014，线性范围为2.5～20.0μg·ml-1。回收率98.81%～99.36%，精密度和稳定性RSD均在2%以内，符合《中国药典》的要求。
목적：건립이자외분광광도법측정아체락이완석미낭함량적방법。방법：장아체락이완석미낭연마파쇄，전이지용량병중，희석후，재224nm처진행함량측정。결과：아체락이재224nm처유최대흡수，보료대측정무간우。표준곡선방정：A=0.0355C+0.0014，선성범위위2.5～20.0μg·ml-1。회수솔98.81%～99.36%，정밀도화은정성RSD균재2%이내，부합《중국약전》적요구。
Objective: to establish a method for determination of atenolol sustained-release microcapsules content by ultraviolet spectrophotometry. Methods:to grind the atenolol sustained-release microcapsules, transferred to a volumetric flask, determining content at 224nm. Results: the atenolol has maximum absorption at 224nm, excipients do not interfere with the determination. standard curve equation: A=0.0355C+0.0014, linear range is 2.5~20.0μg·ml-1. The rate of recovery is 98.81%~99.36%, the precision and stability of RSD are within 2%.