CAJ | 학술논문

目的：探讨理血解毒类方对银屑病患者外周血血管内皮生长因子水平的影响。方法：2012年3月-2013年3月收治寻常型银屑病患者100例，根据证候将患者分为血瘀型组、血燥型组和血热型组，其中血瘀型26例，血燥型30例，血热型44例。对照组无银屑病，共35例。使用酶联免疫吸附法检测口服活血解毒汤、养血解毒汤及凉血解毒汤前后患者的血清 VEGF 水平。结果：银屑病患者血清 VEGF 水平在治疗前较对照组明显升高，差异具有统计学意义(P＜0.05)，血燥型银屑病组治疗前血清VEGF显著低于血热型组，差异具有统计学意义(P＜0.05)；血热型组与血瘀型组比较差异无统计学意义(P＞0.05)；血燥型组与血瘀型组比较血清VEGF差异无统计学意义(P＞0.05)。中药治疗后血燥型和血热组血清VEGF明显降低(P＜0.05)，经中药治疗后血瘀型组血清VEGF与治疗前比较差异无统计学意义(P＞0.05)。结论：银屑病与VEGF变化具有特异性。养血解毒方、凉血解毒方治疗血燥型和血热型银屑病的机制可能为抑制血管生成。
목적：탐토리혈해독류방대은설병환자외주혈혈관내피생장인자수평적영향。방법：2012년3월-2013년3월수치심상형은설병환자100례，근거증후장환자분위혈어형조、혈조형조화혈열형조，기중혈어형26례，혈조형30례，혈열형44례。대조조무은설병，공35례。사용매련면역흡부법검측구복활혈해독탕、양혈해독탕급량혈해독탕전후환자적혈청 VEGF 수평。결과：은설병환자혈청 VEGF 수평재치료전교대조조명현승고，차이구유통계학의의(P＜0.05)，혈조형은설병조치료전혈청VEGF현저저우혈열형조，차이구유통계학의의(P＜0.05)；혈열형조여혈어형조비교차이무통계학의의(P＞0.05)；혈조형조여혈어형조비교혈청VEGF차이무통계학의의(P＞0.05)。중약치료후혈조형화혈열조혈청VEGF명현강저(P＜0.05)，경중약치료후혈어형조혈청VEGF여치료전비교차이무통계학의의(P＞0.05)。결론：은설병여VEGF변화구유특이성。양혈해독방、량혈해독방치료혈조형화혈열형은설병적궤제가능위억제혈관생성。
Objective:To explore the influence of regulating blood antidotal Decoction on psoriatic peripheral blood vascular endothelial growth factor level.Methods:100 patients with psoriasis vulgaris were selected from March 2012 to March 2013.They were divided into the blood dry group with 30 cases, blood heat type with 26 cases and blood stasis type group with 44 cases.35 cases without psoriasis were as the control group.We used enzyme linked immunosorbent assay detected the serum VEGF level of the patients before and after oral Huo Xue Jie Du decoction,detoxification decoction and Liang Xue Jie Du decoction.Results:The serum VEGF level in patients with psoriasis vulgaris before treatment was significantly higher than the control group,with significant difference(P<0.05).Dry psoriasis patients before treatment the serum VEGF was significantly lower than that of blood heat type group,with significant difference(P<0.05).There was no significant difference of blood heat type and blood stasis type group(P>0.05).The level of serum VEGF of blood dryness type group and blood stasis group had no significant difference(P>0.05).After the treatment of traditional Chinese medicine,the serum VEGF level of the blood dryness type and blood heat group decreased significantly(P<0.05).There was no significant difference of serum VEGF level of the blood stasis type group between before the traditional Chinese medicine treatment and after(P>0.05).Conclusion:The psoriasis and VEGF changes has specific. The possible mechanism of detoxification,cooling blood detoxification decoction in the treatment of blood dryness type and blood heat type psoriasis is the inhibition of angiogenesis.