临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
2期
309-311
,共3页
抗生素%序贯疗法%转移因子%急性下呼吸道感染
抗生素%序貫療法%轉移因子%急性下呼吸道感染
항생소%서관요법%전이인자%급성하호흡도감염
antibiotics%antibiotic therapy%transfer factor%acute lower respiratory infections
目的：探讨抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染疗效和安全性。方法174例急性下呼吸道感染儿童患者，随机分为观察组和对照组，每组87例。对照组给予阿奇霉素序贯治疗（常规治疗＋阿奇霉素注射液3 d；再给予常规治疗＋阿奇霉素片5 d），观察组在对照组的基础上加服转移因子4周。对两组患者治疗疗效、症状改善时间、细胞免疫功能、不良反应进行观察。结果观察组治疗总有效率为95.4％，显著高于对照组的86.2％（P＜0.05）；观察组退热时间、咳嗽消失时间为（2.39±0.57）天、（4.73±1.56）天，均显著低于对照组的（3.59±0.5）天、（6.35±1.89）天（P＜0.05）；治疗后观察组患者CD3＋、CD4＋和CD4＋／CD8＋分别为（62.09±12.29）％、（46.38±10.12）％和（1.72±0.76），显著高于对照组的（57.38±9.46）％、（42.43±9.69）％和（1.45±0.67），（P＜0.05）；观察组不良反为3.5％，低于对照组的4.6％（P＞0.05）。结论抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染疗效显著，提高儿童免疫力。
目的：探討抗生素序貫療法聯閤轉移因子治療兒童急性下呼吸道感染療效和安全性。方法174例急性下呼吸道感染兒童患者，隨機分為觀察組和對照組，每組87例。對照組給予阿奇黴素序貫治療（常規治療＋阿奇黴素註射液3 d；再給予常規治療＋阿奇黴素片5 d），觀察組在對照組的基礎上加服轉移因子4週。對兩組患者治療療效、癥狀改善時間、細胞免疫功能、不良反應進行觀察。結果觀察組治療總有效率為95.4％，顯著高于對照組的86.2％（P＜0.05）；觀察組退熱時間、咳嗽消失時間為（2.39±0.57）天、（4.73±1.56）天，均顯著低于對照組的（3.59±0.5）天、（6.35±1.89）天（P＜0.05）；治療後觀察組患者CD3＋、CD4＋和CD4＋／CD8＋分彆為（62.09±12.29）％、（46.38±10.12）％和（1.72±0.76），顯著高于對照組的（57.38±9.46）％、（42.43±9.69）％和（1.45±0.67），（P＜0.05）；觀察組不良反為3.5％，低于對照組的4.6％（P＞0.05）。結論抗生素序貫療法聯閤轉移因子治療兒童急性下呼吸道感染療效顯著，提高兒童免疫力。
목적：탐토항생소서관요법연합전이인자치료인동급성하호흡도감염료효화안전성。방법174례급성하호흡도감염인동환자，수궤분위관찰조화대조조，매조87례。대조조급여아기매소서관치료（상규치료＋아기매소주사액3 d；재급여상규치료＋아기매소편5 d），관찰조재대조조적기출상가복전이인자4주。대량조환자치료료효、증상개선시간、세포면역공능、불량반응진행관찰。결과관찰조치료총유효솔위95.4％，현저고우대조조적86.2％（P＜0.05）；관찰조퇴열시간、해수소실시간위（2.39±0.57）천、（4.73±1.56）천，균현저저우대조조적（3.59±0.5）천、（6.35±1.89）천（P＜0.05）；치료후관찰조환자CD3＋、CD4＋화CD4＋／CD8＋분별위（62.09±12.29）％、（46.38±10.12）％화（1.72±0.76），현저고우대조조적（57.38±9.46）％、（42.43±9.69）％화（1.45±0.67），（P＜0.05）；관찰조불량반위3.5％，저우대조조적4.6％（P＞0.05）。결론항생소서관요법연합전이인자치료인동급성하호흡도감염료효현저，제고인동면역력。
Objective To investigate the efficacy and safety of sequential antibiotic therapy combined with transfer factor therapy in the treatment of children with acute lower respiratory tract infection.Methods 1 74 children with acute lower respiratory tract infection were randomly divided into the observation group and the control group,87 cases in each group.The control group was given azithromycin sequential therapy (conventional therapy +azithromy-cin injection,3d;and then conventional therapy +azithromycin tablets,5d),and the observation group was given transfer factor therapy (4 weeks)based on the control group.Their efficacy,symptoms improved time,immune func-tion,and adverse reactions of the two groups were observed.Results The total effective rate of the observation group was 95.4%,which was significantly higher than that of the control group (86.2%,P<0.05).The time of fever re-lieving and cough disappear in the observation group were (2.39 ±0.57)days and (4.73 ±1.56)days respectively, which were significantly lower than those in the control group [(3.59 ±0.5)days and (6.35 ±1.89)days](P<0.05 ).After the treatment,the levels of CD3+,CD4+and CD4+/CD8+in the observation group were (62.09 ± 1 2.29)%,(46.38 ±1 0.1 2)% and (1.72 ±0.76)respectively,which were significantly higher than those in the control group [(57.38 ±9.46)%,(42.43 ±9.69)%and (1.45 ±0.67)],(P<0.05).The incidence of adverse reactions in the observation group was 3.5%,which was lower than that in the control group (4.6%,P>0.05). Conclusion Sequential antibiotic therapy combined with transfer factor therapy can effectively improve the immunity in the treatment of children with acute lower respiratory infections.
