临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
2期
280-282
,共3页
李怡%刘华%陈其章%马慧
李怡%劉華%陳其章%馬慧
리이%류화%진기장%마혜
降钙素原%红细胞免疫%肺疾病%慢性阻塞性%急性加重期
降鈣素原%紅細胞免疫%肺疾病%慢性阻塞性%急性加重期
강개소원%홍세포면역%폐질병%만성조새성%급성가중기
procalcitonin%erythrocyte innate immune function%chronic obstructive pulmonary disease%a-cute exacerbations
目的：观察慢性阻塞性肺疾病急性加重期（AECOPD）红细胞免疫功能及血清降钙素原（PCT）变化，并观察在抗感染治疗前后两者变化及相关性。方法采用郭峰法和化学发光法测定50例AECOPD患者和40例健康对照者外周血C3b受体花环率（RBC-C3bRR）、红细胞免疫复合物花环率（RBC-ICR）及血清降钙素原（PCT）水平及抗感染治疗前后的动态变化。结果 AECOPD 组治疗前 RBC-C3bRR [（11.21±2.67）％]明显低于治疗后[（13.36±2.75）％]及健康对照组[（15.36±3.02）％]，差异有统计学意义（P均＜0.01）。AECOPD 组治疗前 RBC-ICR 、PCT [（9.05±2.39）％，（0.29±0.15）ng／ml ]明显高于治疗后[（7.95±1.55）％，（0.09±0.03）ng／ml]及健康对照组[（5.89±1.82）％，（0.08±0.05）ng／ml]，差异有统计学意义（P均＜0.01）。AECOPD患者组PCT水平与RBC-C3bRR呈显著负相关（r＝－0.421，P＜0.01），与RBC-ICR呈显著正相关（r＝0.488，P＜0.01）。结论 PCT是早期诊断AECOPD的敏感和有价值的指标，且AECOPD患者存在红细胞免疫功能的下降，可能是临床症状反复发作的原因。
目的：觀察慢性阻塞性肺疾病急性加重期（AECOPD）紅細胞免疫功能及血清降鈣素原（PCT）變化，併觀察在抗感染治療前後兩者變化及相關性。方法採用郭峰法和化學髮光法測定50例AECOPD患者和40例健康對照者外週血C3b受體花環率（RBC-C3bRR）、紅細胞免疫複閤物花環率（RBC-ICR）及血清降鈣素原（PCT）水平及抗感染治療前後的動態變化。結果 AECOPD 組治療前 RBC-C3bRR [（11.21±2.67）％]明顯低于治療後[（13.36±2.75）％]及健康對照組[（15.36±3.02）％]，差異有統計學意義（P均＜0.01）。AECOPD 組治療前 RBC-ICR 、PCT [（9.05±2.39）％，（0.29±0.15）ng／ml ]明顯高于治療後[（7.95±1.55）％，（0.09±0.03）ng／ml]及健康對照組[（5.89±1.82）％，（0.08±0.05）ng／ml]，差異有統計學意義（P均＜0.01）。AECOPD患者組PCT水平與RBC-C3bRR呈顯著負相關（r＝－0.421，P＜0.01），與RBC-ICR呈顯著正相關（r＝0.488，P＜0.01）。結論 PCT是早期診斷AECOPD的敏感和有價值的指標，且AECOPD患者存在紅細胞免疫功能的下降，可能是臨床癥狀反複髮作的原因。
목적：관찰만성조새성폐질병급성가중기（AECOPD）홍세포면역공능급혈청강개소원（PCT）변화，병관찰재항감염치료전후량자변화급상관성。방법채용곽봉법화화학발광법측정50례AECOPD환자화40례건강대조자외주혈C3b수체화배솔（RBC-C3bRR）、홍세포면역복합물화배솔（RBC-ICR）급혈청강개소원（PCT）수평급항감염치료전후적동태변화。결과 AECOPD 조치료전 RBC-C3bRR [（11.21±2.67）％]명현저우치료후[（13.36±2.75）％]급건강대조조[（15.36±3.02）％]，차이유통계학의의（P균＜0.01）。AECOPD 조치료전 RBC-ICR 、PCT [（9.05±2.39）％，（0.29±0.15）ng／ml ]명현고우치료후[（7.95±1.55）％，（0.09±0.03）ng／ml]급건강대조조[（5.89±1.82）％，（0.08±0.05）ng／ml]，차이유통계학의의（P균＜0.01）。AECOPD환자조PCT수평여RBC-C3bRR정현저부상관（r＝－0.421，P＜0.01），여RBC-ICR정현저정상관（r＝0.488，P＜0.01）。결론 PCT시조기진단AECOPD적민감화유개치적지표，차AECOPD환자존재홍세포면역공능적하강，가능시림상증상반복발작적원인。
Objective To observe the changes of erythrocyte innate immune function and procalcitonin (PCT)levels in elderly patients with AECOPD.Methods The rosette rate of red-cell C3b receptors (RBC-C3bRR),red-cell immune complex (RBC-ICR)and serum PCT in the fresh peripheral blood were detected in 50 pa-tients with AECOPD and 40 healthy controls by Guo-Feng method and chemoluminescence respectively.Results The rosette rate of RBC-C3bRR was (1 1.21 ±2.67)%in AECOPD patients before the treatment,which was signifi-cantly lower than that of AECOPD patients after the treatment (1 3.36 ±2.75%)and the healthy controls (1 5.36 ± 3.02%)(P<0.01 ).The levels of RBC-ICR and PCT were (9.05 ±2.39)%and (0.29 ±0.1 5)ng/ml in AECO-PD patients before the treatment,which were obviously higher that those of patients with AECOPD after the treatment (7.95 ±1.55%)and (0.09 ±0.03)ng/ml and (5.89 ±1.82)%and (0.08 ±0.05)ng/ml in the control group (P<0.01 ).Correlation analysis of PCT and RBC-C3bRR in AECOPD patients revealed a significant negative correla-tion (r=-0.421 ,P<0.01 ),and PCT and RBC-ICR showed a significant positive correlation (r=0.488,P<0.01 ).Conclusion Serum PCT is a valuable and sensitive indicator for early diagnosis of AECOPD.AECOPD pa-tients has obvious suppression of erythrocyte innate immune function,which may cause the recurrence of AECOPD.
