CAJ | 학술논문

目的：研究超声与CT引导下射频消融联合靶向治疗对周围型中晚期（Ⅲ与Ⅳ期）非小细胞肺癌患者的治疗价值。方法选取80例周围型中晚期非小细胞肺癌患者随机分为对照组与观察组，每组均为40例。两组患者均给予吉非替尼联合顺铂与紫杉醇靶向治疗，观察组在靶向治疗的基础上行在超声与CT引导下经皮射频消融术，观察两组治疗后的近期及远期临床疗效、不良反应与治疗前后外周血清肿瘤标记物的浓度。结果治疗后观察组临床疗效均优于对照组（P＜0.05），治疗后两组外周血清表皮生长因子受体（EGFR）、鳞状细胞癌相关抗原（SCC）、癌胚抗原（CEA）、糖类抗原（CA125）浓度均明显低于治疗前（P＜0.05），治疗后观察组外周血清EGFR、SCC、CEA、CA125浓度均明显低于对照组（P＜0.05），观察组术后出现咳嗽、胸痛、发热、咯血、气胸，两组靶向治疗后均出现恶心、恶心伴呕吐、骨髓抑制，无统计学差异（P＞0.05）。结论超声与CT引导下射频消融术联合靶向治疗对转移灶较少的周围型中晚期非小细胞肺癌能很好的提高临床疗效，是一种安全可靠且创伤较小的治疗方法，有很好的临床应用前景。
목적：연구초성여CT인도하사빈소융연합파향치료대주위형중만기（Ⅲ여Ⅳ기）비소세포폐암환자적치료개치。방법선취80례주위형중만기비소세포폐암환자수궤분위대조조여관찰조，매조균위40례。량조환자균급여길비체니연합순박여자삼순파향치료，관찰조재파향치료적기출상행재초성여CT인도하경피사빈소융술，관찰량조치료후적근기급원기림상료효、불량반응여치료전후외주혈청종류표기물적농도。결과치료후관찰조림상료효균우우대조조（P＜0.05），치료후량조외주혈청표피생장인자수체（EGFR）、린상세포암상관항원（SCC）、암배항원（CEA）、당류항원（CA125）농도균명현저우치료전（P＜0.05），치료후관찰조외주혈청EGFR、SCC、CEA、CA125농도균명현저우대조조（P＜0.05），관찰조술후출현해수、흉통、발열、각혈、기흉，량조파향치료후균출현악심、악심반구토、골수억제，무통계학차이（P＞0.05）。결론초성여CT인도하사빈소융술연합파향치료대전이조교소적주위형중만기비소세포폐암능흔호적제고림상료효，시일충안전가고차창상교소적치료방법，유흔호적림상응용전경。
Objective To study the value of radiofrequency ablation combined with targeted therapy in the treatment of patients with peripheral non-small cell lung cancer at stage Ⅲ and Ⅳ under ultrasound and CT.Meth-ods 80 patients with peripheral non-small cell lung cancer at stage ⅢandⅣwere randomly divided into the obser-vation group and the control group.All of them were treated with paclitaxel,cisplatin and gefitinib,while the obser-vation group was additionally treated with percutaneous radio frequency ablation.The concentration of tumor markers in serum and clinical efficacy of near future and long-term and adverse reaction were observed and compared between the two groups.Results After the treatment,the concentration of EGFR,SCC,CEA and CA1 25 were lower in the observation group than in the control group (P<0.05 ).Conclusion The treatment of radiofrequency ablation com-bined with targeted therapy can improve the clinical efficiency in the treatment of patients with peripheral non-small cell lung cancer at stage Ⅲ and Ⅳ,with high safety and minor trauma.