国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
24期
3686-3688
,共3页
李锐%孙继林%章军%张修稳
李銳%孫繼林%章軍%張脩穩
리예%손계림%장군%장수은
老年患者%胆囊切除术%C反应蛋白%白细胞介素-6%肿瘤坏死因子
老年患者%膽囊切除術%C反應蛋白%白細胞介素-6%腫瘤壞死因子
노년환자%담낭절제술%C반응단백%백세포개소-6%종류배사인자
Elderly patients%Cholecystectomy%C reactive protein%Interleukin-6%Tumour necrosis factor
目的 探讨经腹腔镜、开腹胆囊切除术对老年患者围手术期血清C反应蛋白、IL-6、TNF-α的影响.方法 选取100例结石性胆囊炎老年患者(年龄＞60岁),根据手术方式分为经腹腔镜胆囊切除术组(LC组,50例)及开腹切除术组(OC组,50例),均于术前1d及术后24 h、48 h、72 h抽取肘静脉血2 ml,分离血清检测C反应蛋白、IL-6、TNF-α含量.结果 术后24 h、48 h、72 h两组血清C反应蛋白、IL-6、TNF-α含量均显著升高(P＜0.01).术后24 h、48 h、72 h LC组的血清C反应蛋白、IL-6、TNF-α含量均显著低于OC组(P＜0.01);术后72 hLC组的血清C反应蛋白含量恢复到术前ld水平(P＞0.05),且下降的幅度较快(P＜0.01).结论 经腹腔镜、开腹胆囊切除术均可引起血清C反应蛋白、IL-6、TNF-α含量升高.LC与OC相比较,LC对于术后老年患者机体免疫功能影响较小.
目的 探討經腹腔鏡、開腹膽囊切除術對老年患者圍手術期血清C反應蛋白、IL-6、TNF-α的影響.方法 選取100例結石性膽囊炎老年患者(年齡＞60歲),根據手術方式分為經腹腔鏡膽囊切除術組(LC組,50例)及開腹切除術組(OC組,50例),均于術前1d及術後24 h、48 h、72 h抽取肘靜脈血2 ml,分離血清檢測C反應蛋白、IL-6、TNF-α含量.結果 術後24 h、48 h、72 h兩組血清C反應蛋白、IL-6、TNF-α含量均顯著升高(P＜0.01).術後24 h、48 h、72 h LC組的血清C反應蛋白、IL-6、TNF-α含量均顯著低于OC組(P＜0.01);術後72 hLC組的血清C反應蛋白含量恢複到術前ld水平(P＞0.05),且下降的幅度較快(P＜0.01).結論 經腹腔鏡、開腹膽囊切除術均可引起血清C反應蛋白、IL-6、TNF-α含量升高.LC與OC相比較,LC對于術後老年患者機體免疫功能影響較小.
목적 탐토경복강경、개복담낭절제술대노년환자위수술기혈청C반응단백、IL-6、TNF-α적영향.방법 선취100례결석성담낭염노년환자(년령＞60세),근거수술방식분위경복강경담낭절제술조(LC조,50례)급개복절제술조(OC조,50례),균우술전1d급술후24 h、48 h、72 h추취주정맥혈2 ml,분리혈청검측C반응단백、IL-6、TNF-α함량.결과 술후24 h、48 h、72 h량조혈청C반응단백、IL-6、TNF-α함량균현저승고(P＜0.01).술후24 h、48 h、72 h LC조적혈청C반응단백、IL-6、TNF-α함량균현저저우OC조(P＜0.01);술후72 hLC조적혈청C반응단백함량회복도술전ld수평(P＞0.05),차하강적폭도교쾌(P＜0.01).결론 경복강경、개복담낭절제술균가인기혈청C반응단백、IL-6、TNF-α함량승고.LC여OC상비교,LC대우술후노년환자궤체면역공능영향교소.
Objective To investigate the influence of laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) on serum C reactive protein,IL-6,TNF-α in elderly patients.Methods 100 elderly patients with calculous cholecystitis were randomly divided into LC group and OC group,with 50 cases in each group.All of the patients were phlebotomized 2 ml fasting elbow venous blood 1 day before surgery,24,48,72 hours after surgery.The levels of serum C reactive protein,IL-6,TNF-α were detected by enzyme linked immunosorbent assay (ELISA).Results The levels of C reactive protein,Ⅱ-6,TNF-α significantly increased 24,48,72 h after surgery in both two groups (P ＜ 0.01).The levels of C reactive protein,IL-6,TNF-α in LC group 24,48,72 h after surgery were significantly lower than those in OC group (P ＜ 0.01).The level of C reactive protein in LC group 72 h after surgery returned back to the level on the first day before surgery (P ＞ 0.05),with a faster decline speed (P ＜ 0.01).Conclusion Laparoscopic cholecystectomy and open cholecystectomy would both lead to the raise of serum C reactive protein,IL-6,TNF-α.Compared with open cholecystectomy,laparoscopic cholecystectomy has little influence on immune function in elderly patients after surgery.
