CAJ | 학술논문

COPD相关肺动脉高压(PH)的发生发展与肺部组织慢性炎症密切相关,在COPD相关PH的肺血管收缩及重塑中血小板活化因子(PAF)起重要作用.PAF是一种具有广泛生物学活性的内源性磷脂类炎症介质,能够活化血小板及其他炎症细胞.PAF的主要降解酶是血小板活化因子乙酰水解酶(PAF-AH),其通过水解PAF及相关的氧化磷脂在炎症反应中发挥调节作用.本文就PAF、PAF-AH在COPD相关PH中的作用作一综述.
COPD상관폐동맥고압(PH)적발생발전여폐부조직만성염증밀절상관,재COPD상관PH적폐혈관수축급중소중혈소판활화인자(PAF)기중요작용.PAF시일충구유엄범생물학활성적내원성린지류염증개질,능구활화혈소판급기타염증세포.PAF적주요강해매시혈소판활화인자을선수해매(PAF-AH),기통과수해PAF급상관적양화린지재염증반응중발휘조절작용.본문취PAF、PAF-AH재COPD상관PH중적작용작일종술.
The development of chronic obstructive pulmonary disease (COPD) associated pulmonary hypertension (PH) is correlated closely with inflammation.Platelet-activating factor (PAF) plays an important role in pulmonary vasoconstriction and rebuilding of COPD associated PH.PAF is a kind of endogenous phospholipids mediums,which has broad biological activity,and could make platelets and other inflammatory cells active.The major catabolic enzyme of PAF is platelet-activating factor acetyl hydrolase (PAF-AH).PAF-AH plays an important regulatory role by hydrolyzing PAF and related oxidized phospholipids.In this paper,the role of PAF and PAF-AH in patients with COPD associated PH are reviewed.