国际医学寄生虫病杂志
國際醫學寄生蟲病雜誌
국제의학기생충병잡지
INTERNATIONAL JOURNAL OF MEDICAL PARASITIC DISEASES
2014年
6期
334-336
,共3页
彭国华%胡主花%周义生%冯小武%陈海婴%郭家钢
彭國華%鬍主花%週義生%馮小武%陳海嬰%郭傢鋼
팽국화%호주화%주의생%풍소무%진해영%곽가강
防护霜%吡喹酮%血吸虫尾蚴
防護霜%吡喹酮%血吸蟲尾蚴
방호상%필규동%혈흡충미유
External cream%Praziquantel%Schistosoma cercaria
目的 观察吡喹酮外用霜剂预防血吸虫尾蚴感染的效果. 方法 用含吡喹酮的1%和2%外用防护霜剂,采用即时接触感染实验和水冲延迟接触感染实验两种方式对昆明小鼠进行预防血吸虫尾蚴感染的实验,同时用去氯水做对照.观察不同浓度、不同方式感染后小白鼠和对照组小白鼠的肝脏外观及镜下虫卵结果,同时对检获的血吸虫成虫数进行比较,实验组和对照组的成虫数采用方差分析进行比较,两种实验方式之间的成虫数采用t检验进行比较. 结果 两种剂型、两种实验方式的小鼠解剖后,肝脏均呈鲜红色,表面光滑,压片镜检均未发现虫卵,也未检获血吸虫成虫,而对照组小鼠肝脏均色暗,有不同程度的表面结节,压片镜检均发现了散在或成堆的血吸虫卵,同时检获了不同数量的血吸虫成虫,即时接触感染实验对照组检获的成虫数为(6.17±3.86)条,水冲延迟接触感染实验对照组检获的成虫数为(9.50±3.98)条.两种方式对照组与实验组检获血吸虫成虫数比较,其差异具有统计学意义(F=14.316,P<0.01; F=20.990,P<0.01),两种方式对照组检获血吸虫成虫数之间比较差异无统计学意义(t=-1.159,P>0.05). 结论 吡喹酮外用霜剂能较好地防御血吸虫尾蚴感染.
目的 觀察吡喹酮外用霜劑預防血吸蟲尾蚴感染的效果. 方法 用含吡喹酮的1%和2%外用防護霜劑,採用即時接觸感染實驗和水遲延遲接觸感染實驗兩種方式對昆明小鼠進行預防血吸蟲尾蚴感染的實驗,同時用去氯水做對照.觀察不同濃度、不同方式感染後小白鼠和對照組小白鼠的肝髒外觀及鏡下蟲卵結果,同時對檢穫的血吸蟲成蟲數進行比較,實驗組和對照組的成蟲數採用方差分析進行比較,兩種實驗方式之間的成蟲數採用t檢驗進行比較. 結果 兩種劑型、兩種實驗方式的小鼠解剖後,肝髒均呈鮮紅色,錶麵光滑,壓片鏡檢均未髮現蟲卵,也未檢穫血吸蟲成蟲,而對照組小鼠肝髒均色暗,有不同程度的錶麵結節,壓片鏡檢均髮現瞭散在或成堆的血吸蟲卵,同時檢穫瞭不同數量的血吸蟲成蟲,即時接觸感染實驗對照組檢穫的成蟲數為(6.17±3.86)條,水遲延遲接觸感染實驗對照組檢穫的成蟲數為(9.50±3.98)條.兩種方式對照組與實驗組檢穫血吸蟲成蟲數比較,其差異具有統計學意義(F=14.316,P<0.01; F=20.990,P<0.01),兩種方式對照組檢穫血吸蟲成蟲數之間比較差異無統計學意義(t=-1.159,P>0.05). 結論 吡喹酮外用霜劑能較好地防禦血吸蟲尾蚴感染.
목적 관찰필규동외용상제예방혈흡충미유감염적효과. 방법 용함필규동적1%화2%외용방호상제,채용즉시접촉감염실험화수충연지접촉감염실험량충방식대곤명소서진행예방혈흡충미유감염적실험,동시용거록수주대조.관찰불동농도、불동방식감염후소백서화대조조소백서적간장외관급경하충란결과,동시대검획적혈흡충성충수진행비교,실험조화대조조적성충수채용방차분석진행비교,량충실험방식지간적성충수채용t검험진행비교. 결과 량충제형、량충실험방식적소서해부후,간장균정선홍색,표면광활,압편경검균미발현충란,야미검획혈흡충성충,이대조조소서간장균색암,유불동정도적표면결절,압편경검균발현료산재혹성퇴적혈흡충란,동시검획료불동수량적혈흡충성충,즉시접촉감염실험대조조검획적성충수위(6.17±3.86)조,수충연지접촉감염실험대조조검획적성충수위(9.50±3.98)조.량충방식대조조여실험조검획혈흡충성충수비교,기차이구유통계학의의(F=14.316,P<0.01; F=20.990,P<0.01),량충방식대조조검획혈흡충성충수지간비교차이무통계학의의(t=-1.159,P>0.05). 결론 필규동외용상제능교호지방어혈흡충미유감염.
Objective To observe the effect of praziquantel external cream preventing skin invasion from Schistosoma cercariae.Methods Experimental mice were spread with 1% or 2% praziquantel external cream on the shaved abdomen skin respectively before infection,control group mice were treated with free-chloride water the same way.The instant contact and delay contact infection experiment with free-chloride water washing methods were used to carry out the infection of schistosome cercaria.The appearance and Schistosoma eggs of the mice liver in both experimental and control group were observed under microscope.Meanwhile,the number of Schistosomajaponicum worms was compared.The number of adult worms between the experimental group and the control group was compared by analysis of variance,the number of adults between two kinds of experimental methods was compared using t test.Results The liver surface of experimental group mice was smooth.Eggs and worms were not found.However,the livers of control group mice were dark in color with nodules of different degree on surface,scattered or piles of schistosome eggs were found under microscopy,and various number of adult Schistosoma were collected.There were 6.17±3.86 and 9.50±3.98 adults found in the control group of instant contact infection experiment and delay contact infection experiment respectively.There was significant difference of adult Schistosoma number between experimental and control group at two different methods(F=14.316,P<0.01 ; F=20.990,P<0.01).There was no significant difference of adult Schistosoma number between two control groups(t=-1.159,P>0.05).Conclusion Praziquantel external cream has efficiency on preventing Schistosoma cercariae from skin invading.