CAJ | 학술논문

目的调查深圳市首例境外输入性卵形疟患者的发病和诊疗过程,为科学防治卵形疟提供借鉴. 方法收集患者的临床和流行病学资料,采集外周血作涂片镜检疟原虫,疟疾快速诊断试验(rapid diagnostic test,RDT)检测疟原虫特异性抗原,巢式PCR扩增富色氨酸抗原基因鉴定基因型.结果患者由非洲几内亚疟疾流行区回国,具有寒战、发热、出汗等临床症状.血涂片查见疟原虫,受感染红细胞呈伞矢状,薛氏点明显,可见滋养体、裂殖体和配子体,形态特点与卵形疟原虫相符;但疟疾RDT抗原检测结果为阴性;基因分型鉴定为卵形疟原虫wallikeri新亚种,采用青蒿琥酯片与磷酸伯氨喹联合用药治愈. 结论根据患者流行病学史、临床表现以及实验室检测结果判断为一宗输入性卵形疟个案.
목적 조사심수시수례경외수입성란형학환자적발병화진료과정,위과학방치란형학제공차감. 방법 수집환자적림상화류행병학자료,채집외주혈작도편경검학원충,학질쾌속진단시험(rapid diagnostic test,RDT)검측학원충특이성항원,소식PCR확증부색안산항원기인감정기인형.결과 환자유비주궤내아학질류행구회국,구유한전、발열、출한등림상증상.혈도편사견학원충,수감염홍세포정산시상,설씨점명현,가견자양체、렬식체화배자체,형태특점여란형학원충상부;단학질RDT항원검측결과위음성;기인분형감정위란형학원충wallikeri신아충,채용청호호지편여린산백안규연합용약치유. 결론 근거환자류행병학사、림상표현이급실험실검측결과판단위일종수입성란형학개안.
Objective To investigate the first imported case of P.ovale malaria in Shenzhen area for providing reference for the diagnosis and treatment.Methods The clinical history and epidemiological information were collected.The Plasmodium parasite in blood sample was detected and identified by microscopy,malaria rapid diagnostic test and nested PCR methods.Results The patient returned from malaria endemic areas in Guinea on Jan 24,2014,and developed symptoms of chill,fever and sudation,which lasted about 3hr every day since Mar 3,2014.The different blood stages of P.ovale were observed under microscopy,with fimbriated edges of infected red blood cells.The P.ovale was identified as P.ovale wallikeri by nested PCR.However,the RDT test was negative.The patient was cured with artesunate combined with primaquine phosphate.Conclusion The case was an imported P.ovale malaria according to epidemiological,clinical manifestations and laboratory examination results.