国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2014年
10期
746-750
,共5页
曾宪卿%何俊%张晨辉%段言峰%陆兵勋
曾憲卿%何俊%張晨輝%段言峰%陸兵勛
증헌경%하준%장신휘%단언봉%륙병훈
卒中%脑缺血%颈动脉疾病%8-异构前列腺素F2α%氧化性应激%生物学标记%危险因素
卒中%腦缺血%頸動脈疾病%8-異構前列腺素F2α%氧化性應激%生物學標記%危險因素
졸중%뇌결혈%경동맥질병%8-이구전렬선소F2α%양화성응격%생물학표기%위험인소
Stroke%Brain Ischemia%Carotid Artery Diseases%8-Epi-Prostaglandin F2α%Oxidative Stress%Biological Markers%Risk Factors
目的 探讨急性缺血性卒中患者尿8-异前列腺素F2α(8-iso-prostaglandin F2α,8-iso-PGF2α)水平与颈动脉粥样硬化斑块稳定性的关系.方法 连续纳入急性缺血性卒中患者,根据颈部血管超声检查结果分为无斑块组和斑块组,再将斑块组分为稳定斑块组和不稳定斑块组.采用酶联免疫吸附法检测尿8-iso-PGF2α水平.应用多变量logistic回归分析和Spearman相关分析探讨8-iso-PGF2α与颈动脉斑块的关系.结果 共纳入150例急性缺血性卒中患者,其中104例存在颈动脉斑块(30例为稳定斑块,74例为不稳定斑块),46例无颈动脉斑块.斑块组尿8-iso-PGF2α水平[(86.45±6.20) ng/mmol肌酐对(45.70±6.19) ng/mmol肌酐;=37.136,P=0.00l]以及颈动脉内膜-中膜厚度(intima-media thickness,IMT)[(2.89±1.03) mm对(0.86±0.53)mm;t=3.518,P=0.002]显著性高于无斑块组.多变量logistic回归分析显示,尿8-iso-PGF2α水平[优势比(odds ratio,OR)1.183,95％可信区间(confidence interval,CI)1.087～1.276;P=0.00l]和IMT(OR 28.642,95％ CI8.276 ～ 137.231;P=0.001)是颈动脉斑块的独立危险因素;Pearson相关性分析显示,尿8-iso-PGF2α水平与颈动脉IMT无显著相关性(r=0.075,P=0.264).不稳定斑块组尿8-iso-PGF2α水平显著高于稳定斑块组[(97.30±7.20) ng/mmol肌酐对(69.17±9.25) ng/mmol肌酐;t=16.506,P=0.001],多变量logistic回归分析显示,8-iso-PGF2α水平(OR4.652,95％ CI 1.732 ～ 12.643;P=0.001)是斑块不稳定的独立危险因素.结论 在缺血性卒中患者中,8-jso-PGF2α水平与颈动脉斑块的存在和不稳定性相关,其水平增高是颈动脉斑块不稳定的独立危险因素.
目的 探討急性缺血性卒中患者尿8-異前列腺素F2α(8-iso-prostaglandin F2α,8-iso-PGF2α)水平與頸動脈粥樣硬化斑塊穩定性的關繫.方法 連續納入急性缺血性卒中患者,根據頸部血管超聲檢查結果分為無斑塊組和斑塊組,再將斑塊組分為穩定斑塊組和不穩定斑塊組.採用酶聯免疫吸附法檢測尿8-iso-PGF2α水平.應用多變量logistic迴歸分析和Spearman相關分析探討8-iso-PGF2α與頸動脈斑塊的關繫.結果 共納入150例急性缺血性卒中患者,其中104例存在頸動脈斑塊(30例為穩定斑塊,74例為不穩定斑塊),46例無頸動脈斑塊.斑塊組尿8-iso-PGF2α水平[(86.45±6.20) ng/mmol肌酐對(45.70±6.19) ng/mmol肌酐;=37.136,P=0.00l]以及頸動脈內膜-中膜厚度(intima-media thickness,IMT)[(2.89±1.03) mm對(0.86±0.53)mm;t=3.518,P=0.002]顯著性高于無斑塊組.多變量logistic迴歸分析顯示,尿8-iso-PGF2α水平[優勢比(odds ratio,OR)1.183,95％可信區間(confidence interval,CI)1.087～1.276;P=0.00l]和IMT(OR 28.642,95％ CI8.276 ～ 137.231;P=0.001)是頸動脈斑塊的獨立危險因素;Pearson相關性分析顯示,尿8-iso-PGF2α水平與頸動脈IMT無顯著相關性(r=0.075,P=0.264).不穩定斑塊組尿8-iso-PGF2α水平顯著高于穩定斑塊組[(97.30±7.20) ng/mmol肌酐對(69.17±9.25) ng/mmol肌酐;t=16.506,P=0.001],多變量logistic迴歸分析顯示,8-iso-PGF2α水平(OR4.652,95％ CI 1.732 ～ 12.643;P=0.001)是斑塊不穩定的獨立危險因素.結論 在缺血性卒中患者中,8-jso-PGF2α水平與頸動脈斑塊的存在和不穩定性相關,其水平增高是頸動脈斑塊不穩定的獨立危險因素.
목적 탐토급성결혈성졸중환자뇨8-이전렬선소F2α(8-iso-prostaglandin F2α,8-iso-PGF2α)수평여경동맥죽양경화반괴은정성적관계.방법 련속납입급성결혈성졸중환자,근거경부혈관초성검사결과분위무반괴조화반괴조,재장반괴조분위은정반괴조화불은정반괴조.채용매련면역흡부법검측뇨8-iso-PGF2α수평.응용다변량logistic회귀분석화Spearman상관분석탐토8-iso-PGF2α여경동맥반괴적관계.결과 공납입150례급성결혈성졸중환자,기중104례존재경동맥반괴(30례위은정반괴,74례위불은정반괴),46례무경동맥반괴.반괴조뇨8-iso-PGF2α수평[(86.45±6.20) ng/mmol기항대(45.70±6.19) ng/mmol기항;=37.136,P=0.00l]이급경동맥내막-중막후도(intima-media thickness,IMT)[(2.89±1.03) mm대(0.86±0.53)mm;t=3.518,P=0.002]현저성고우무반괴조.다변량logistic회귀분석현시,뇨8-iso-PGF2α수평[우세비(odds ratio,OR)1.183,95％가신구간(confidence interval,CI)1.087～1.276;P=0.00l]화IMT(OR 28.642,95％ CI8.276 ～ 137.231;P=0.001)시경동맥반괴적독립위험인소;Pearson상관성분석현시,뇨8-iso-PGF2α수평여경동맥IMT무현저상관성(r=0.075,P=0.264).불은정반괴조뇨8-iso-PGF2α수평현저고우은정반괴조[(97.30±7.20) ng/mmol기항대(69.17±9.25) ng/mmol기항;t=16.506,P=0.001],다변량logistic회귀분석현시,8-iso-PGF2α수평(OR4.652,95％ CI 1.732 ～ 12.643;P=0.001)시반괴불은정적독립위험인소.결론 재결혈성졸중환자중,8-jso-PGF2α수평여경동맥반괴적존재화불은정성상관,기수평증고시경동맥반괴불은정적독립위험인소.
Objective To investigate the correlation between urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) level and carotid atherosclerotic plaque stability in patients with acute ischemic stroke.Methods The patients with acute ischemic stroke were enrolled consecutively.According to the findings of carotid artery ultrasound,they were divided into either a non-plaque group or a plaque group,and then the plaque group was redivided into a stable plaque subgroup and an unstable plaque subgroup.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of urinary 8-iso-PGF2α.Multivariate logistic regression analysis and Spearman correlation analysis were used to investigate the relationship between 8-iso-PGF2α and carotid artery plaques.Results A total of 150 patients with acute ischemic stroke were enrolled,including 104 had carotid artery plaque (30 were stable plaques and 74 were unstable plaques) and 46 had no carotid artery plaque.The urinary 8-iso-PGF2α level (86.45 ± 6.20 ng/mmol creatinine vs.45.70 ±6.19 ng/mmol creatinine; t =37.136,P=0.001) and intima-media thickness (IMT) (2.89 ± 1.03 mm vs.0.86 ±0.53 mm; t =3.518,P =0.002) in the plaque group were significantly higher than those in the nonplaque group.Multivariate logistic regression analysis showed that urinary 8-iso-PGF2α level (odds ratio [OR] 1.183,95％ confidence interval [CI] 1.087-1.276; P=0.001) and IMT (OR 28.642,95％ CI 8.276-137.231; P =0.001) were the independent risk factors for carotid artery plaque.Pearson correlation analysis showed that there was no significant correlation between urinary 8-iso-PGF2α level and carotid artery IMT (r =0.075,P =0.264).The urinary 8-iso-PGF2α level of the unstable plaque subgroup was significantly higher than that of the stable plaque subgroup (97.30 ± 7.20 ng/mmol creatinine vs.69.17 ±9.25 ng/mmol creatinine; t =16.506,P =0.001).Multivariate logistic regression analysis showed that urinary 8-iso-PGF2α level (OR 4.652,95％ CI 1.732-12.643; P =0.001) was an independent risk factor for unstable plaque.Conelusions The urinary 8-iso-PGF2α level is associated with the existence of carotid atherosclerotie plaque and instability,its increased level is an independent risk factor for carotid plaque instability in patients with ischemic stroke.
