CAJ | 학술논문

目的评估肝硬化患者肝性脑病发生率与终末期肝病模型(MELD)评分的关系.方法对120例失代偿期肝硬化患者进行MELD评分,并观察患者肝性脑病的发生情况.结果 120例失代偿期肝硬化患者中发生肝性脑病53例,发生率为44.17％(53/120).肝性脑病患者MELD评分为(21.69±9.22)分,非肝性脑病患者MELD评分为(9.32±4.63)分,两者比较差异有统计学意义(P＜0.05).肝性脑病发生率随MELD评分的增高而增加(P＜0.01).MELD评分预测患者发生肝性脑病的最佳临界值是14.13分(敏感度86.05％,特异度88.37％),MELD评分≥14.13分患者3个月内肝性脑病发生率显著高于MELD评分＜14.13分患者[63.16％(48/76)比11.36％(5/44)],差异有统计学意义(x2=30.32,P＜0.01).结论 MELD评分有助于预测失代偿期肝硬化患者肝性脑病的发生率.
목적 평고간경화환자간성뇌병발생솔여종말기간병모형(MELD)평분적관계.방법 대120례실대상기간경화환자진행MELD평분,병관찰환자간성뇌병적발생정황.결과 120례실대상기간경화환자중발생간성뇌병53례,발생솔위44.17％(53/120).간성뇌병환자MELD평분위(21.69±9.22)분,비간성뇌병환자MELD평분위(9.32±4.63)분,량자비교차이유통계학의의(P＜0.05).간성뇌병발생솔수MELD평분적증고이증가(P＜0.01).MELD평분예측환자발생간성뇌병적최가림계치시14.13분(민감도86.05％,특이도88.37％),MELD평분≥14.13분환자3개월내간성뇌병발생솔현저고우MELD평분＜14.13분환자[63.16％(48/76)비11.36％(5/44)],차이유통계학의의(x2=30.32,P＜0.01).결론 MELD평분유조우예측실대상기간경화환자간성뇌병적발생솔.
Objective To evaluate the relationship between the incidence rate of hepatic encephalopathy in patients with cirrhosis and the model for end-stage liver disease (MELD).Methods The total of 120 patients with decompensated cirrhosis were enrolled and followed-up.MELD score was obtained to observe the incidence of hepatic encephalopathy.Results The incidence of hepatic encephalopathy was 44.17％(53/120).MELD score in hepatic encephalopathy patients was significantly higher than that in none hepatic encephalopathy patients[(21.69 ± 9.22) scores vs.(9.32 ± 4.63) scores],and there was significant difference (P ＜ 0.05).With the increase of MELD score,the incidence of hepatic encephalopathy increased (P ＜ 0.01).The best critical value of MELD score was 14.13 scores (the sensitivity of 86.05％ and the specificity of 88.37％),when MELD ≥14.13 scores,the incidence of hepatic encephalopathy within 3 months was significantly higher [63.16％(48/76) vs.11.36％(5/44)] (x2 =30.32,P＜ 0.01).Conclusion MELD can help predicting the incidence of hepatic encephalopathy in decompensated cirrhosis patients.