中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
11期
1156-1158
,共3页
卢维晟%刘芳%张江蓉%袁惠敏%王一尘
盧維晟%劉芳%張江蓉%袁惠敏%王一塵
로유성%류방%장강용%원혜민%왕일진
急性心肌梗死%高血糖%老年人%超敏C反应蛋白%B型脑钠肽%心室重构
急性心肌梗死%高血糖%老年人%超敏C反應蛋白%B型腦鈉肽%心室重構
급성심기경사%고혈당%노년인%초민C반응단백%B형뇌납태%심실중구
Myocardial infarction,acute%Hyperglycemia%Elder%Hypersensitive C-reaction protein%B-type natriuretic peptide%Ventricular remodeling
目的 探讨高血糖对老年急性心肌梗死(AMI)患者超敏C反应蛋白(hs-CRP)、B型脑钠肽(BNP)和心室重构的影响.方法 120例老年AMI患者,根据入院血糖水平分为两组,高血糖组60例(入院时血糖≥7.8 mmol/L)和非高血糖组60例(入院时血糖＜7.8 mmol/L).检测两组患者入院时血糖、血清hs-CRP和BNP,心脏超声检测入院时和2周后左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)和室壁运动积分(WMS)的指标.结果 高血糖组入院时血糖、BNP和hs-CRP分别为(9.6±0.6)mmol/L、(1 750.6±677.1)ng/L、(56.1 ±38.6) ng/L,显著高于非高血糖组(5.7±0.5)mmol/L、(497.2±450.3)ng/L、(36.3±26.2)ng/L(t值分别为38.7、11.9、3.3,P均＜0.01);高血糖组患者心脏超声指标LVEF、LVEDD、LVESD和WMS治疗前、后比较差异均无统计学意义(P均＞0.05).非高血糖组患者治疗前、后LVEF[(52.51±10.01)％与(56.4±9.5)％]、LVEDD[(50.2±5.6) mm与(53.0±5.2) mm]、LVESD[(36.8±6.2)mm与(41.0±6.2) mm]和WMS[(2.1±0.7)分与(2.9±1.0)分]均有统计学意义(t值分别为2.049、2.836、3.814、2.086,P均＜0.05).结论 高血糖可导致hs-CRP、BNP升高,对AMI老年患者的心室重构产生影响,但更多机制需要深入研究.
目的 探討高血糖對老年急性心肌梗死(AMI)患者超敏C反應蛋白(hs-CRP)、B型腦鈉肽(BNP)和心室重構的影響.方法 120例老年AMI患者,根據入院血糖水平分為兩組,高血糖組60例(入院時血糖≥7.8 mmol/L)和非高血糖組60例(入院時血糖＜7.8 mmol/L).檢測兩組患者入院時血糖、血清hs-CRP和BNP,心髒超聲檢測入院時和2週後左心室射血分數(LVEF)、左心室舒張末期內徑(LVEDD)、左心室收縮末期內徑(LVESD)和室壁運動積分(WMS)的指標.結果 高血糖組入院時血糖、BNP和hs-CRP分彆為(9.6±0.6)mmol/L、(1 750.6±677.1)ng/L、(56.1 ±38.6) ng/L,顯著高于非高血糖組(5.7±0.5)mmol/L、(497.2±450.3)ng/L、(36.3±26.2)ng/L(t值分彆為38.7、11.9、3.3,P均＜0.01);高血糖組患者心髒超聲指標LVEF、LVEDD、LVESD和WMS治療前、後比較差異均無統計學意義(P均＞0.05).非高血糖組患者治療前、後LVEF[(52.51±10.01)％與(56.4±9.5)％]、LVEDD[(50.2±5.6) mm與(53.0±5.2) mm]、LVESD[(36.8±6.2)mm與(41.0±6.2) mm]和WMS[(2.1±0.7)分與(2.9±1.0)分]均有統計學意義(t值分彆為2.049、2.836、3.814、2.086,P均＜0.05).結論 高血糖可導緻hs-CRP、BNP升高,對AMI老年患者的心室重構產生影響,但更多機製需要深入研究.
목적 탐토고혈당대노년급성심기경사(AMI)환자초민C반응단백(hs-CRP)、B형뇌납태(BNP)화심실중구적영향.방법 120례노년AMI환자,근거입원혈당수평분위량조,고혈당조60례(입원시혈당≥7.8 mmol/L)화비고혈당조60례(입원시혈당＜7.8 mmol/L).검측량조환자입원시혈당、혈청hs-CRP화BNP,심장초성검측입원시화2주후좌심실사혈분수(LVEF)、좌심실서장말기내경(LVEDD)、좌심실수축말기내경(LVESD)화실벽운동적분(WMS)적지표.결과 고혈당조입원시혈당、BNP화hs-CRP분별위(9.6±0.6)mmol/L、(1 750.6±677.1)ng/L、(56.1 ±38.6) ng/L,현저고우비고혈당조(5.7±0.5)mmol/L、(497.2±450.3)ng/L、(36.3±26.2)ng/L(t치분별위38.7、11.9、3.3,P균＜0.01);고혈당조환자심장초성지표LVEF、LVEDD、LVESD화WMS치료전、후비교차이균무통계학의의(P균＞0.05).비고혈당조환자치료전、후LVEF[(52.51±10.01)％여(56.4±9.5)％]、LVEDD[(50.2±5.6) mm여(53.0±5.2) mm]、LVESD[(36.8±6.2)mm여(41.0±6.2) mm]화WMS[(2.1±0.7)분여(2.9±1.0)분]균유통계학의의(t치분별위2.049、2.836、3.814、2.086,P균＜0.05).결론 고혈당가도치hs-CRP、BNP승고,대AMI노년환자적심실중구산생영향,단경다궤제수요심입연구.
Objective To explore the impact of hyperglycemia on Hypersensitive C-reaction protein (hsCRP),B-type natriuretic peptide(BNP) and ventricular remodeling in elder patients with acute myocardial infarction(AMI).Methods One hundred and twenty elder patients with AMI are divided into hyperglycemia group(blood sugar in admission ＞ 7.8 mmol/L) and non-glycemia group(blood sugar in admission ≤7.8 mmol/L).The levels of blood sugar in admission,hsCRP,BNP were detected.LVEF,LVEDD,LVESD,WMS were observed by cardiac echo in admission and two weeks after therapy.Results The blood sugar in admission,hsCRP and BNP of the patients in hyperglycemia group were (9.6 ± 0.6) mmol/L,(1 750.6 ±677.1) ng/L,(56.1 ±38.6) ng/L,higher than those in non-glycemia group (t =38.679 and P =0.000; t =11.941 and P =0.000; t =3.288 and P ＜0.01,respectively).LVEF,LVEDD,LVESD and WMS of patients in hyperglycemia group didn't show statistical significance before and after therapy.However,there were significant in hyperglycemia group (t =2.049 and P =0.043,t =2.836 and P =0.005,t =3.814 and P =0.000,t =2.086 and P =0.039,respectively).Conclusion Hyperglycemia can reduce the increase of hsCRP and BNP,which has an impact on hsCRP,BNP and ventricular remodeling in elder patients with acute myocardial infarction,but the mechanism need to further research.
