CAJ | 학술논문

目的探讨宁夏地区变应性鼻炎(allergic rhinitis,AR)与微量元素的关系,为AR的预防和诊治提供参考.方法将2010年1-12月就诊于宁夏医科大学总医院诊断为AR的患者106例作为试验组,其中常年性AR 48例,季节性AR 58例,并以健康志愿者103例作为对照组.抽取所有研究对象静脉血3 ～5 ml,采用电感耦合等离子体原子发射光谱(ICP-AES)法测定入选对象血清中微量元素Ca、Ni、Fe、Mg、Zn、Sr、Mn、Cu、Se的含量;剪取AR患者及健康志愿者头发少许,采用上述方法检测相关微量元素的含量,以SPSS 16.0软件进行统计学分析,采用t检验分别比较AR组与健康对照组,常年性AR组与季节性AR组血清及头发中微量元素的差异.结果 AR组血清中Zn、Se的含量分别为(793.48±46.88)、(84.25±12.77) μg/L,低于对照组的(908.53±31.26)、(98.35±15.21) μg/L,差异有统计学意义(t值分别为-24.175、-7.797,P值均＜0.05);AR组血清中Cu、Ni含量分别为(1 002.18±104.62) μg/L、(21.58±5.54) mg/L,高于对照组的(832.78±50.45) μg/L、(17.04±4.93) mg/L,差异有统计学意义(t值分别为15.545、5.154,P值均＜0.05).AR组头发中Zn、Se的含量分别为(92.16±4.54)、(0.28±0.04) μg/g,低于对照组的(189.09±8.45)、(0.39±0.06) μg/g,差异有统计学意义(t值分别为-28.71、-8.633,P值均＜0.05);AR组头发中Cu、Ni含量分别为(42.43±5.03)、(31.72±5.49)μg/g,高于对照组的(23.00±4.45)、(8.94±7.53) μg/g,差异有统计学意义(t值分别为-8.633、4.236,P值均＜0.05).常年性与季节性AR患者血清微量元素含量差异无统计学意义(P值均＞0.05).结论 AR患者血清微量元素Zn、Se低于健康对照组中的含量,而Cu、Ni高于健康对照组.常年性AR患者与季节性AR患者血清中微量元素含量无明显差异.
목적 탐토저하지구변응성비염(allergic rhinitis,AR)여미량원소적관계,위AR적예방화진치제공삼고.방법 장2010년1-12월취진우저하의과대학총의원진단위AR적환자106례작위시험조,기중상년성AR 48례,계절성AR 58례,병이건강지원자103례작위대조조.추취소유연구대상정맥혈3 ～5 ml,채용전감우합등리자체원자발사광보(ICP-AES)법측정입선대상혈청중미량원소Ca、Ni、Fe、Mg、Zn、Sr、Mn、Cu、Se적함량;전취AR환자급건강지원자두발소허,채용상술방법검측상관미량원소적함량,이SPSS 16.0연건진행통계학분석,채용t검험분별비교AR조여건강대조조,상년성AR조여계절성AR조혈청급두발중미량원소적차이.결과 AR조혈청중Zn、Se적함량분별위(793.48±46.88)、(84.25±12.77) μg/L,저우대조조적(908.53±31.26)、(98.35±15.21) μg/L,차이유통계학의의(t치분별위-24.175、-7.797,P치균＜0.05);AR조혈청중Cu、Ni함량분별위(1 002.18±104.62) μg/L、(21.58±5.54) mg/L,고우대조조적(832.78±50.45) μg/L、(17.04±4.93) mg/L,차이유통계학의의(t치분별위15.545、5.154,P치균＜0.05).AR조두발중Zn、Se적함량분별위(92.16±4.54)、(0.28±0.04) μg/g,저우대조조적(189.09±8.45)、(0.39±0.06) μg/g,차이유통계학의의(t치분별위-28.71、-8.633,P치균＜0.05);AR조두발중Cu、Ni함량분별위(42.43±5.03)、(31.72±5.49)μg/g,고우대조조적(23.00±4.45)、(8.94±7.53) μg/g,차이유통계학의의(t치분별위-8.633、4.236,P치균＜0.05).상년성여계절성AR환자혈청미량원소함량차이무통계학의의(P치균＞0.05).결론 AR환자혈청미량원소Zn、Se저우건강대조조중적함량,이Cu、Ni고우건강대조조.상년성AR환자여계절성AR환자혈청중미량원소함량무명현차이.
Objective To investigate the correlation of allergic rhinitis and trace elements and to provide a reference for clinical diagnosis,treatment and prevention of allergic rhinitis.Methods One hundred and six patients were diagnosed as allergic rhinitis in General Hospital of Ningxia Medical University between January and December in 2010,including 48 cases of perennial allergic rhinitis and 58 cases of seasonal allergic rhinitis.In the same time,one hundred and three healthy volunteers were selected as control.Intravenous blood 3-5 ml were obtained from all subjects both in experimental group and in control group.The content of Ca,Ni,Fe,Mg,Zn,Sr,Mn,Cu,Se in serum and hair was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES).The t-test (SPSS 16.0) was used to compare the results of trace elements in serum between allergic rhinitis and control group.Results The testing results of trace elements in AR patients serum and normal controls serum were as follows:Cu,Ni (1 002.18 ± 104.62) μg/L,(21.58 ± 5.54) mg/L were super than control group,(832.78 ± 50.45) μg/L,(17.04 ±4.93) mg/L(t value was 15.545,5.154,both P ＜0.05).But the content of Zn,Se (793.48 ± 46.88) μg/L,(84.25 ± 12.77) μg/L lower than control group (908.53 ± 31.26) μg/L,(98.35 ± 15.21) μg/L (t value was-24.175 and-7.797,both P ＜0.05).The testing results of trace elements in AR patients hair and normal controls hair were as follows:Cu,Ni (42.43 ± 5.03) μg/g,(31.72±5.49) μg/g were super than control group,(23.00±4.45) μg/g,(8.94±7.53) μg/g (t value was-8.633 and 4.236,both P ＜ 0.05).But the content of Zn,Se (92.16 ± 4.54) μg/g,(0.28 ±0.04) μg/g lower than control group (189.09 ± 8.45) μg/g,(0.39 ± 0.06) μg/g (t value was-28.71 and-8.633,both P ＜ 0.05).Conclusions The content of Zn,Se in AR patients serum are lower than that in control group.But the content of Cu,Ni in AR patients serum are super than that in control group.There are no significant difference of trace elements in the serum between pennial allergic rhinitis and seasonal allergic rhinitis.