中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2014年
12期
810-814
,共5页
陈智勇%胡伟%郭子维%王燕%曹孟淑%孙凌云
陳智勇%鬍偉%郭子維%王燕%曹孟淑%孫凌雲
진지용%호위%곽자유%왕연%조맹숙%손릉운
多发性肌炎%皮肌炎%肺疾病,间质性%抗核基质蛋白2抗体
多髮性肌炎%皮肌炎%肺疾病,間質性%抗覈基質蛋白2抗體
다발성기염%피기염%폐질병,간질성%항핵기질단백2항체
Polymyositis%Dermatomyositis%Lung disease,interstitial%Anti-nuclear matrix protein antibody
目的 探讨汉族人抗核基质蛋白2(NXP2)抗体阳性多发性肌炎/皮肌炎(PM/DM)患者的临床特点.方法 采用免疫沉降-蛋白印迹法对141例汉族成人PM/DM患者进行抗NXP2抗体检测,收集阳性患者的临床资料进行回顾性分析,复习国内外文献并与之比较.采用x2检验和Fisher确切概率法进行统计学处理.结果 共有7例(5％)患者抗NXP2抗体阳性,其中DM患者6例,PM患者1例.和文献报道的114例抗NXP2阳性患者类似,汉族抗NXP2阳性患者多有肌无力、向阳疹和Gottron征.与抗体阴性患者相比,抗体阳性患者吞咽困难[43％(3/7)和9％(12/134),x2=8.04,P=0.027)]和肢体肿胀[(43％(3/7)和2％(3/134),x2=26.94,P=0.001 4)]的发生率较高.未发现明显恶性肿瘤相关性.结论 在汉族成人中,抗NXP2抗体主要见于DM,患者吞咽困难和肢体肿胀的发生率较高.
目的 探討漢族人抗覈基質蛋白2(NXP2)抗體暘性多髮性肌炎/皮肌炎(PM/DM)患者的臨床特點.方法 採用免疫沉降-蛋白印跡法對141例漢族成人PM/DM患者進行抗NXP2抗體檢測,收集暘性患者的臨床資料進行迴顧性分析,複習國內外文獻併與之比較.採用x2檢驗和Fisher確切概率法進行統計學處理.結果 共有7例(5％)患者抗NXP2抗體暘性,其中DM患者6例,PM患者1例.和文獻報道的114例抗NXP2暘性患者類似,漢族抗NXP2暘性患者多有肌無力、嚮暘疹和Gottron徵.與抗體陰性患者相比,抗體暘性患者吞嚥睏難[43％(3/7)和9％(12/134),x2=8.04,P=0.027)]和肢體腫脹[(43％(3/7)和2％(3/134),x2=26.94,P=0.001 4)]的髮生率較高.未髮現明顯噁性腫瘤相關性.結論 在漢族成人中,抗NXP2抗體主要見于DM,患者吞嚥睏難和肢體腫脹的髮生率較高.
목적 탐토한족인항핵기질단백2(NXP2)항체양성다발성기염/피기염(PM/DM)환자적림상특점.방법 채용면역침강-단백인적법대141례한족성인PM/DM환자진행항NXP2항체검측,수집양성환자적림상자료진행회고성분석,복습국내외문헌병여지비교.채용x2검험화Fisher학절개솔법진행통계학처리.결과 공유7례(5％)환자항NXP2항체양성,기중DM환자6례,PM환자1례.화문헌보도적114례항NXP2양성환자유사,한족항NXP2양성환자다유기무력、향양진화Gottron정.여항체음성환자상비,항체양성환자탄인곤난[43％(3/7)화9％(12/134),x2=8.04,P=0.027)]화지체종창[(43％(3/7)화2％(3/134),x2=26.94,P=0.001 4)]적발생솔교고.미발현명현악성종류상관성.결론 재한족성인중,항NXP2항체주요견우DM,환자탄인곤난화지체종창적발생솔교고.
Objective To investigate the clinical features of polymyositis/dermatomyositis (PM/DM) with anti-nuclear matrix protein (anti-2NXP2) antibodies in Han-Chinese.Methods ImmunoprecipitationWestern Blotting (IP-WB) method was used for screening anti-NXP2 antibodies in 141 adult Han-Chinese patients with PM/DM.The clinical and laboratory data were collected,analyzed and compared with the antiNXP2-positive patients reported in the literature.Statistical analyses were performed using chi-square test and Fisher's exact test.Results Seven (5％) patients,including 6 with DM and 1 with PM,were identified as anti-NXP2 positive.Consistent with the 114 anti-NXP2-positive patients reported in the literature,Han patients with anti-NXP2 had higher frequencies of weakness,heliotrope rash and Gottron's sign.Compared with anti-NXP2-negative patients,anti-NXP2-positive patients presented significantly higher frequencies of dysphagia [43％(3/7) vs 9％(12/134),x2=8.04,P=0.027] and edema [43％(3/7) vs 2％(3/134),x2=26.94,P=0.001 4],while an absence of PM/DM related cancer was observed in Han patients with anti-NXP2.Conclusion Adult Han-Chinese patients with anti-NXP2 are DM predominant,and are characterized by a high frequencies of edema and dysphagia.
