中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2014年
12期
913-916
,共4页
周祥福%刘柏隆%陈雪莲%湛海伦%李文标%杨飞%李腾成%孙其鹏
週祥福%劉柏隆%陳雪蓮%湛海倫%李文標%楊飛%李騰成%孫其鵬
주상복%류백륭%진설련%담해륜%리문표%양비%리등성%손기붕
膀胱炎,间质性%神经纤维密度%视觉模拟评分
膀胱炎,間質性%神經纖維密度%視覺模擬評分
방광염,간질성%신경섬유밀도%시각모의평분
Cystitis,interstitial%Nerve fiber density%Visual analogue scale
目的 探讨间质性膀胱炎(interstitial cystitis,IC)患者膀胱组织神经纤维密度与疼痛症状的相关性,明确其在IC膀胱疼痛中的作用. 方法 选取2006年1月至2012年4月收治的51例IC患者为实验组(男9例,女42例),25例非IC患者的正常膀胱组织为对照组.两组均进行视觉模拟评分法(visual analogue scale,VAS)疼痛评分、PGP9.5单克隆抗体免疫组化和神经纤维计数.结果 两组膀胱组织的神经纤维密度分别为(4.78±1.47)、(3.53±1.19)条/cm2(P=0.021);IC伴疼痛组、IC无疼痛组的神经纤维密度分别为(5.56±1.85)、(3.82±1.34)条/cm2(P=0.018),IC无疼痛组与对照组比较差异无统计学意义(P=0.164);轻度、中度、重度疼痛组的神经纤维密度分别为(4.95±1.52)、(5.37±1.76)、(5.83±1.91)条/cm2,三组比较差异有统计学意义(F=4.698,P=0.023),两两比较差异也有统计学意义(P中/轻=0.034,P重/中=0.029).神经纤维密度与VAS疼痛评分呈正相关(r=0.332,P=0.015). 结论 IC伴疼痛组膀胱组织的神经纤维密度高于IC无疼痛组和正常对照组,且IC膀胱组织的神经纤维密度与疼痛症状评分成正相关,提示IC患者膀胱组织神经纤维增多与膀胱疼痛密切相关.
目的 探討間質性膀胱炎(interstitial cystitis,IC)患者膀胱組織神經纖維密度與疼痛癥狀的相關性,明確其在IC膀胱疼痛中的作用. 方法 選取2006年1月至2012年4月收治的51例IC患者為實驗組(男9例,女42例),25例非IC患者的正常膀胱組織為對照組.兩組均進行視覺模擬評分法(visual analogue scale,VAS)疼痛評分、PGP9.5單剋隆抗體免疫組化和神經纖維計數.結果 兩組膀胱組織的神經纖維密度分彆為(4.78±1.47)、(3.53±1.19)條/cm2(P=0.021);IC伴疼痛組、IC無疼痛組的神經纖維密度分彆為(5.56±1.85)、(3.82±1.34)條/cm2(P=0.018),IC無疼痛組與對照組比較差異無統計學意義(P=0.164);輕度、中度、重度疼痛組的神經纖維密度分彆為(4.95±1.52)、(5.37±1.76)、(5.83±1.91)條/cm2,三組比較差異有統計學意義(F=4.698,P=0.023),兩兩比較差異也有統計學意義(P中/輕=0.034,P重/中=0.029).神經纖維密度與VAS疼痛評分呈正相關(r=0.332,P=0.015). 結論 IC伴疼痛組膀胱組織的神經纖維密度高于IC無疼痛組和正常對照組,且IC膀胱組織的神經纖維密度與疼痛癥狀評分成正相關,提示IC患者膀胱組織神經纖維增多與膀胱疼痛密切相關.
목적 탐토간질성방광염(interstitial cystitis,IC)환자방광조직신경섬유밀도여동통증상적상관성,명학기재IC방광동통중적작용. 방법 선취2006년1월지2012년4월수치적51례IC환자위실험조(남9례,녀42례),25례비IC환자적정상방광조직위대조조.량조균진행시각모의평분법(visual analogue scale,VAS)동통평분、PGP9.5단극륭항체면역조화화신경섬유계수.결과 량조방광조직적신경섬유밀도분별위(4.78±1.47)、(3.53±1.19)조/cm2(P=0.021);IC반동통조、IC무동통조적신경섬유밀도분별위(5.56±1.85)、(3.82±1.34)조/cm2(P=0.018),IC무동통조여대조조비교차이무통계학의의(P=0.164);경도、중도、중도동통조적신경섬유밀도분별위(4.95±1.52)、(5.37±1.76)、(5.83±1.91)조/cm2,삼조비교차이유통계학의의(F=4.698,P=0.023),량량비교차이야유통계학의의(P중/경=0.034,P중/중=0.029).신경섬유밀도여VAS동통평분정정상관(r=0.332,P=0.015). 결론 IC반동통조방광조직적신경섬유밀도고우IC무동통조화정상대조조,차IC방광조직적신경섬유밀도여동통증상평분성정상관,제시IC환자방광조직신경섬유증다여방광동통밀절상관.
Objective To investigate the relationship of nerve fiber density in bladder tissues and pain symptom in patients with interstitial cystitis (IC),in order to understand its role in the bladder pain of IC patients.Methods The experimental group included 51 cases of IC patients (9 male,42 female) and the control group included 25 cases with normal bladder tissue.All the cases underwent visual analogue scale (VAS) pain scores,immunohistochemistry of the PGP9.5 monoclonal antibody and nerve fiber counting.Results The nerve fiber density of the bladder tissue in the 2 groups was 4.78± 1.47/cm2,3.53± 1.19 /cm2,respectively (P=0.021).The nerve fiber density of IC with pain group and IC without pain group was 5.56±1.85/cm2,3.82±1.34/cm2,respectively (P=0.018).There was no significant difference in nerve fiber density between IC without pain group and the control group (P =0.164).The nerve fiber density of mild pain group,moderate pain group,severe pain group was 4.95± 1.52/cm2,5.37± 1.76/cm2,5.83± 1.91 /cm2,respectively,and the differences were significant (F=4.698,P=0.023; Pmoderate/mild =0.034,P /mod =0.029).Furthermore,the nerve fiber density of IC was positively correlated with VAS pain score (r=0.332,P=0.015).Conclusions The density of nerve fibers in bladder tissues of IC with pain group is higher than that of IC without pain group and normal controls,and it has a positive relationship with pain symptom scores,which suggestes that high expression of nerve fibers in bladder tissues may play an important role in the bladder pain of IC patients.
