CAJ | 학술논문

胰岛β细胞再生治疗是糖尿病治疗领域的热点.成年人的β细胞以极低的自我复制速率进行增殖,但在胰岛素抵抗状态下,β细胞能够获得显著的再生能力,因此,有关胰岛素抵抗如何诱导β细胞增生的研究具有极其重要的临床意义.研究表明,胰岛素抵抗通过肝脏分泌的Betatrophin促进了β细胞增生.笔者研究团队2014年7月于《Diabetes Care》在线发表论著“初诊2型糖尿病患者血清Betatrophin水平升高”,旨在揭示糖尿病与Betatrophin的关系.
이도β세포재생치료시당뇨병치료영역적열점.성년인적β세포이겁저적자아복제속솔진행증식,단재이도소저항상태하,β세포능구획득현저적재생능력,인차,유관이도소저항여하유도β세포증생적연구구유겁기중요적림상의의.연구표명,이도소저항통과간장분비적Betatrophin촉진료β세포증생.필자연구단대2014년7월우《Diabetes Care》재선발표론저“초진2형당뇨병환자혈청Betatrophin수평승고”,지재게시당뇨병여Betatrophin적관계.
Replenishing the insulin-producing β cell mass is considered to be a hot topic in the field of diabetes treatment.It has long been known that pancreatic β cells are generated primarily by self-duplication in adults.However,insulin resistance can induce dramatic compensatory β cell mass expansion in the pancreas.Therefore,it is of great value to investigate the etiology and pathogenesis of β cell proliferation under insulin resistance.The recent study has shown that betatrophin,a protein secreted by the liver,modulates β cell growth in response to insulin resistance.We published one article in Diabetes Care titled " Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients " to elaborate the relationship between diabetes and betatrophin.