中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
12期
1058-1062
,共5页
王蕴慧%张培%赵会丹%王振花%陈欣%张睿
王蘊慧%張培%趙會丹%王振花%陳訢%張睿
왕온혜%장배%조회단%왕진화%진흔%장예
甲状腺功能异常%患病率%妊娠
甲狀腺功能異常%患病率%妊娠
갑상선공능이상%환병솔%임신
Thyroid dysfunction%Prevalence%Pregnancy
目的 了解妊娠期各种甲状腺疾病的患病率,并评估甲状腺疾病与妊娠结局的关系.方法 选取2012年3月至2014年2月在中山大学孙逸仙纪念医院产检的3 745名孕妇为研究对象,在孕期进行甲状腺功能(TT4、FT4、TSH)、甲状腺过氧化物酶抗体的检测,结果异常者定期复查,追踪妊娠结局.结果 妊娠期甲状腺疾病的患病率:甲状腺功能亢进(甲亢)1.90％,亚临床甲亢1.20％,甲状腺功能减退(甲减)1.17％,亚临床甲减6.78％,单纯低甲状腺素血症3.82％.临床甲亢组胎盘早剥发生率较正常组高(5.8％对1.0％,P＜0.01).亚临床甲亢组妊娠期糖尿病发生率较正常组高(37.5％对16.6％,P＜0.01).亚临床甲减组早产率较正常组高(14.3％对7.7％,P=0.002).结论 不同类型的妊娠期甲状腺疾病可能会分别增加胎盘早剥、妊娠期糖尿病及早产的发生率.
目的 瞭解妊娠期各種甲狀腺疾病的患病率,併評估甲狀腺疾病與妊娠結跼的關繫.方法 選取2012年3月至2014年2月在中山大學孫逸仙紀唸醫院產檢的3 745名孕婦為研究對象,在孕期進行甲狀腺功能(TT4、FT4、TSH)、甲狀腺過氧化物酶抗體的檢測,結果異常者定期複查,追蹤妊娠結跼.結果 妊娠期甲狀腺疾病的患病率:甲狀腺功能亢進(甲亢)1.90％,亞臨床甲亢1.20％,甲狀腺功能減退(甲減)1.17％,亞臨床甲減6.78％,單純低甲狀腺素血癥3.82％.臨床甲亢組胎盤早剝髮生率較正常組高(5.8％對1.0％,P＜0.01).亞臨床甲亢組妊娠期糖尿病髮生率較正常組高(37.5％對16.6％,P＜0.01).亞臨床甲減組早產率較正常組高(14.3％對7.7％,P=0.002).結論 不同類型的妊娠期甲狀腺疾病可能會分彆增加胎盤早剝、妊娠期糖尿病及早產的髮生率.
목적 료해임신기각충갑상선질병적환병솔,병평고갑상선질병여임신결국적관계.방법 선취2012년3월지2014년2월재중산대학손일선기념의원산검적3 745명잉부위연구대상,재잉기진행갑상선공능(TT4、FT4、TSH)、갑상선과양화물매항체적검측,결과이상자정기복사,추종임신결국.결과 임신기갑상선질병적환병솔:갑상선공능항진(갑항)1.90％,아림상갑항1.20％,갑상선공능감퇴(갑감)1.17％,아림상갑감6.78％,단순저갑상선소혈증3.82％.림상갑항조태반조박발생솔교정상조고(5.8％대1.0％,P＜0.01).아림상갑항조임신기당뇨병발생솔교정상조고(37.5％대16.6％,P＜0.01).아림상갑감조조산솔교정상조고(14.3％대7.7％,P=0.002).결론 불동류형적임신기갑상선질병가능회분별증가태반조박、임신기당뇨병급조산적발생솔.
Objective The purpose of this research is to calculate the prevalence of thyroid dysfunction during pregnancy and to discuss the relationship between gestational thyroid diseases and pregnancy outcomes.Methods There were 3 745 pregnant women who took antenatal care at Sun Yat-sen Memorial Hospital,Sun Yat-sen University were chosen as the research objects during March 2012 to February 2014.All of them were given close monitoring and tracking till the termination of pregnancy.These subjects took thyroid function testing (TT4,FT4,TSH,thyroid peroxidase antibody),if the result was abnormal,they were followed up periodically.Results The prevalence of overt hyperthyroidism is 1.90％,1.20％ for subclinical hyperthyroidism,1.17％ for hypothyroidism,6.78％ for subclinical hypothyroidism,and 3.82％ for isolated hypothyroxinemia.Compared with normal thyroid function group,the morbidity of placental abruption increased in overt hyperthyroidism group (5.8％ vs 1.0％,P＜ 0.01) ; the incidence of gestational diabetes mellitus was increased in subclinical hyperthyroidism group (37.5 ％ vs 16.6％,P＜0.01) ; and the morbidity of preterm birth increased in subclinical hypothyroidism group (14.3％ vs 7.7％,P =0.002).Conclusion Gestational thyroid diseases may increase the incidence of adverse pregnancy outcomes ; such as placental abruption,gestational diabetes mellitus,and premature birth.
