中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2014年
12期
1239-1242
,共4页
刘梦%马建华%张小宁%孙其孟
劉夢%馬建華%張小寧%孫其孟
류몽%마건화%장소저%손기맹
5-脂氧合酶激活蛋白%单核苷酸多态性%缺血性脑卒中%维吾尔族
5-脂氧閤酶激活蛋白%單覈苷痠多態性%缺血性腦卒中%維吾爾族
5-지양합매격활단백%단핵감산다태성%결혈성뇌졸중%유오이족
5-1ipoxygenase-activating gene%Single-nucleotide polymorphism%Ischemic stroke%Uygur
目的 探讨5-脂氧合酶激活蛋白(ALOX5AP)基因多态性与新疆维吾尔族人群缺血性脑卒中发病的关系. 方法 选择自2011年10月至2012年10月就诊于新疆地区各三甲医院神经内科并确诊为急性缺血性脑卒中的当地长住维吾尔族患者197例(病例组)与同期体检的健康维吾尔族人群200例(对照组)为研究对象,应用聚合酶链反应-限制性片段长度多态性技术检测ALOX5AP基因SG13S32位点多态性,采用病例-对照设计统计分析基因型分布和等位基因频率的差异. 结果 ALOX5AP基因SG13S32位点的AC基因型在病例组与对照组间分布差异有统计学意义(P＜0.05),能显著提高缺血性脑卒中的发病风险(OR=5.27,95％CI:2.75～11.73).病例组男女患者间各基因型分布差异无统计学意义(P＞0.05).病例组不同TOAST分型中基因型分布差异无统计学意义(P＞0.05). 结论 ALOX5AP基因SG13S32位点的AC基因型可增加维吾尔族缺血性脑卒中的发病风险,但与性别、TOAST分型无相关性.
目的 探討5-脂氧閤酶激活蛋白(ALOX5AP)基因多態性與新疆維吾爾族人群缺血性腦卒中髮病的關繫. 方法 選擇自2011年10月至2012年10月就診于新疆地區各三甲醫院神經內科併確診為急性缺血性腦卒中的噹地長住維吾爾族患者197例(病例組)與同期體檢的健康維吾爾族人群200例(對照組)為研究對象,應用聚閤酶鏈反應-限製性片段長度多態性技術檢測ALOX5AP基因SG13S32位點多態性,採用病例-對照設計統計分析基因型分佈和等位基因頻率的差異. 結果 ALOX5AP基因SG13S32位點的AC基因型在病例組與對照組間分佈差異有統計學意義(P＜0.05),能顯著提高缺血性腦卒中的髮病風險(OR=5.27,95％CI:2.75～11.73).病例組男女患者間各基因型分佈差異無統計學意義(P＞0.05).病例組不同TOAST分型中基因型分佈差異無統計學意義(P＞0.05). 結論 ALOX5AP基因SG13S32位點的AC基因型可增加維吾爾族缺血性腦卒中的髮病風險,但與性彆、TOAST分型無相關性.
목적 탐토5-지양합매격활단백(ALOX5AP)기인다태성여신강유오이족인군결혈성뇌졸중발병적관계. 방법 선택자2011년10월지2012년10월취진우신강지구각삼갑의원신경내과병학진위급성결혈성뇌졸중적당지장주유오이족환자197례(병례조)여동기체검적건강유오이족인군200례(대조조)위연구대상,응용취합매련반응-한제성편단장도다태성기술검측ALOX5AP기인SG13S32위점다태성,채용병례-대조설계통계분석기인형분포화등위기인빈솔적차이. 결과 ALOX5AP기인SG13S32위점적AC기인형재병례조여대조조간분포차이유통계학의의(P＜0.05),능현저제고결혈성뇌졸중적발병풍험(OR=5.27,95％CI:2.75～11.73).병례조남녀환자간각기인형분포차이무통계학의의(P＞0.05).병례조불동TOAST분형중기인형분포차이무통계학의의(P＞0.05). 결론 ALOX5AP기인SG13S32위점적AC기인형가증가유오이족결혈성뇌졸중적발병풍험,단여성별、TOAST분형무상관성.
Objective To investigate the relationship of the 5-lipoxygenase-activating (ALOX5AP) gene polymorphisms with ischemic stroke in Uygur Xinjiang.Methods One hundred and ninety-seven Uygur patients with ischemic stroke and 200 Uygur healthy controls in Xinjiang were collected in our study from October 2011 to October 2012.The SG13S32 locus polymorphisms of A LOX5A P gene were determined by using PCR-restriction fragment length polymorphism technique.The case-control analysis was used to analyze the genotypes distributions and allele frequencies.Results There were statistical differences in the distributions of AC genotypes of SG13S32 locus in ALOX5AP gene between patient group and control group (P＜0.05) and AC genotypes of SG13S32 locus in ALOX5AP gene significantly increased the risk of ischemic stroke (OR=5.27,95％CI:2.75-11.73).The distributions of all genotypes showed no statistical differences between male and female in the patient group (P＞0.05).The distributions of all genotypes showed no statistical differences between patients of different TOAST ratio (P＞0.05).Conclusion The ALOX5A P gene SG13S32 locus polymorphisms are associated with risk of ischemic stroke in Xinjiang Uygur population; risk of ischemic stroke does not associate with gender and TOAST ratio.
