CAJ | 학술논문

目的分析影响胶质母细胞瘤全切术后患者预后的相关因素. 方法选择北京天坛医院和北京天坛普华医院神经外科自2007年11月至2009年11月手术切除的胶质母细胞瘤患者39例,其中术后行单纯放化疗患者26例(对照组),术后除单纯放化疗外,添加热量限制饮食+心理引导+高压氧同步辅助化疗(CRPH)患者13例(实验组).比较2组患者的生存曲线,分析胶质母细胞瘤患者临床资料与生存期的相关性. 结果实验组患者的生存期[(36.6±12.6)月]比对照组[(19.1±11.3)月]长,实验组患者的累计生存率比对照组高,差异均有统计学意义(P＜0.05).是否添加CRPH、手术次数与胶质母细胞瘤患者的生存期呈正相关关系(P＜0.05);肿瘤体积、Ki-67、O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)、血管内皮生长因子(VEGF)表达强度与生存期呈负相关关系(P＜0.05). 结论 CRPH可以明显延长胶质母细胞瘤患者的生存期.肿瘤体积、手术次数、MGMT、Ki-67、VEGF阳性率均与患者生存期相关.
목적 분석영향효질모세포류전절술후환자예후적상관인소. 방법 선택북경천단의원화북경천단보화의원신경외과자2007년11월지2009년11월수술절제적효질모세포류환자39례,기중술후행단순방화료환자26례(대조조),술후제단순방화료외,첨가열량한제음식+심리인도+고압양동보보조화료(CRPH)환자13례(실험조).비교2조환자적생존곡선,분석효질모세포류환자림상자료여생존기적상관성. 결과 실험조환자적생존기[(36.6±12.6)월]비대조조[(19.1±11.3)월]장,실험조환자적루계생존솔비대조조고,차이균유통계학의의(P＜0.05).시부첨가CRPH、수술차수여효질모세포류환자적생존기정정상관관계(P＜0.05);종류체적、Ki-67、O6-갑기조표령-DNA갑기전이매(MGMT)、혈관내피생장인자(VEGF)표체강도여생존기정부상관관계(P＜0.05). 결론 CRPH가이명현연장효질모세포류환자적생존기.종류체적、수술차수、MGMT、Ki-67、VEGF양성솔균여환자생존기상관.
Objective To research the influence of partial correlation factors in the prognosis of patients suffered glioblastoma multiforme (GBM) after total resection.Methods Thirty-nine patients,admitted to our hospitals from November 2007 to November 2009 and performed total resection,were chosen in our study; after the resections,26 patients (control group) accepted radiotherapies and chemotherapies; 13 patients (experimental group) were furthermore treated by caloric restriction combined with psychotherapy and chemotherapy associated by hybaroxia (CRPH).Survival curve of the two groups were compared; the correlations of clinical data of the GBM patients with survival time were analyzed.Results The survival time in the experimental group ([36.6 ±12.6] months) were significantly longer than that in the control group ([19.1 ±11.3] months,P＜0.05); the cumulative survival rate in the experimental group was significantly higher than that in the control group (P＜0.05).CRPH and resection times were significantly positively correlated with the prognosis of GBM (P=0.000 and 0.013).Volume of tumor was negatively correlated with the prognosis of GBM significantly (P=0.013).Ki-67,O6-methylguanine-DNA methyltransferase (MGMT) and vascular endothelial growth factor (VEGF) were significantly correlated with the prognosis ofGBM (P=0.001,0.022 and 0.001).Conclusions CRPH can apparently prolong the life span of the patients suffered GBM.The volume of tumor,and MGMT,Ki-67 and VEGF levels are correlated to the prognosis of GBM.