CAJ | 학술논문

目的观察根据基因检测结果制定个体化化疗方案治疗晚期肿瘤的疗效.方法晚期肿瘤非一线治疗的25例患者为研究组,收集患者的手术或穿刺标本,应用测序法检测不同基因mRNA表达水平,筛选最适合的化疗药物,进行个体化治疗.20例根据传统经验及循证医学证据选择治疗方案的患者为对照组.比较两组病例有效率及疾病控制率之间的差异.结果研究组有效率44％(11/25),疾病控制率84％(21/25);对照组有效率15％(3/20),疾病控制率35％(7/20).两组差异均有统计学意义(x2=4.36,P＜ 0.05;x 2=11.35,P＜0.05).结论根据治疗靶标检测结果,对晚期肿瘤患者实施个体化治疗,可能提高有效率,延长患者生存期,值得推广.
목적 관찰근거기인검측결과제정개체화화료방안치료만기종류적료효.방법 만기종류비일선치료적25례환자위연구조,수집환자적수술혹천자표본,응용측서법검측불동기인mRNA표체수평,사선최괄합적화료약물,진행개체화치료.20례근거전통경험급순증의학증거선택치료방안적환자위대조조.비교량조병례유효솔급질병공제솔지간적차이.결과 연구조유효솔44％(11/25),질병공제솔84％(21/25);대조조유효솔15％(3/20),질병공제솔35％(7/20).량조차이균유통계학의의(x2=4.36,P＜ 0.05;x 2=11.35,P＜0.05).결론 근거치료파표검측결과,대만기종류환자실시개체화치료,가능제고유효솔,연장환자생존기,치득추엄.
Objective To explore the effect of individualized chemotherapy plans which was designed depend on secific genetic characters in patients with advanced cancer.Methods The surgery or biopsy specimen samples from 25 patients with advanced recurrent tumors (study group) were analyzed.Different gene mRNA expressions were detected by PCR and sequencing.According to detection results,the most appropriate chemotherapy would be applied on 25 cases patients of study group.The chemotherapy from traditional experience and evidence-based medical evidence were applied for 20 cases patients of control group.The difference of RR and disease control rate (DCR) between two groups were compared.Results The DCR and RR were 84 ％ (21/25) and 44 ％ (11/25) in study group,35 ％ (7/20) and 15 ％ (3/20) in control group.The DCR and RR in study group were significantly higher than those in control group (P ＜ 0.01).Conclusion Individualized chemotherapy could improve the efficient and prolong the survival period of the patients with advanced recurrent tumors.