肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
11期
785-788
,共4页
肿瘤%哺乳动物雷帕霉素靶蛋白%反馈激活机制
腫瘤%哺乳動物雷帕黴素靶蛋白%反饋激活機製
종류%포유동물뢰파매소파단백%반궤격활궤제
Neoplasms%Mammalian target of rapamycin%Feedback activation mechanism
哺乳动物雷帕霉素靶蛋白(mTOR)作为生长因子和氨基酸特别是亮氨酸所激发的信号通路的汇合点,在肿瘤细胞中起中心调控作用.近些年,人们逐渐认识到mTOR的反馈激活机制是影响雷帕霉素及其类似物抗肿瘤疗效的重要因素之一.因此,针对mTOR的反馈激活机制及联合应用相关抑制剂协同阻断这一机制的研究成为肿瘤防治的新热点.
哺乳動物雷帕黴素靶蛋白(mTOR)作為生長因子和氨基痠特彆是亮氨痠所激髮的信號通路的彙閤點,在腫瘤細胞中起中心調控作用.近些年,人們逐漸認識到mTOR的反饋激活機製是影響雷帕黴素及其類似物抗腫瘤療效的重要因素之一.因此,針對mTOR的反饋激活機製及聯閤應用相關抑製劑協同阻斷這一機製的研究成為腫瘤防治的新熱點.
포유동물뢰파매소파단백(mTOR)작위생장인자화안기산특별시량안산소격발적신호통로적회합점,재종류세포중기중심조공작용.근사년,인문축점인식도mTOR적반궤격활궤제시영향뢰파매소급기유사물항종류료효적중요인소지일.인차,침대mTOR적반궤격활궤제급연합응용상관억제제협동조단저일궤제적연구성위종류방치적신열점.
As the meeting point of signaling pathways actived by growth factors and amino acids,especially leucine,in tumor cells,mammalian target of rapamycin (mTOR) plays an important role as a center factor of regulation.Recently,it was acknowledged gradually that feedback activation mechanisms of mTOR can influence the efficiency of rapamycin and its analogs in antitumor therapy.Thus,the study about feedback mechanism of mTOR and the combination therapy of mTOR inhibitors and specificd pathway inhibitors has become the hot area in cancer therapy and prevention.
