CAJ | 학술논문

目的探讨白介素-17(IL-17)在重症肺炎患者外周血中的表达及其意义.方法选取我院2013年6月至2014年6月收治的重症肺炎患者56例,根据其APACHEⅡ评分分组,APACHEⅡ评分＜20分为A组,APACHE Ⅱ评分＞20分为B组.30名健康人作为对照组.采用ELISA检测各组患者外周血IL-17含量,最后运用相关对照分析来比较各组间的差异.结果与健康对照人群比较重症肺炎患者外周血中的IL-17明显升高(P＜0.05).与APACHEⅡ评分较低的重症肺炎患者比较,APACHEⅡ评分较高的重症肺炎患者外周血中的IL-17升高更明显(P＜0.05).结论重症肺炎患者Th17细胞分泌的IL-17较健康人群增加,而且增加的程度与疾病严重程度有关,提示IL-17在重症肺炎的发病及进展中扮演重要的角色.
목적 탐토백개소-17(IL-17)재중증폐염환자외주혈중적표체급기의의.방법 선취아원2013년6월지2014년6월수치적중증폐염환자56례,근거기APACHEⅡ평분분조,APACHEⅡ평분＜20분위A조,APACHE Ⅱ평분＞20분위B조.30명건강인작위대조조.채용ELISA검측각조환자외주혈IL-17함량,최후운용상관대조분석래비교각조간적차이.결과 여건강대조인군비교중증폐염환자외주혈중적IL-17명현승고(P＜0.05).여APACHEⅡ평분교저적중증폐염환자비교,APACHEⅡ평분교고적중증폐염환자외주혈중적IL-17승고경명현(P＜0.05).결론 중증폐염환자Th17세포분비적IL-17교건강인군증가,이차증가적정도여질병엄중정도유관,제시IL-17재중증폐염적발병급진전중분연중요적각색.
Objective To investigate the expression and connotation of peripheral interleuk-17(IL-17) in patients with severe pnemonia.Methods A total of 56 cases with severe pneumonia were selected in our hospital from June 2013 to June 2014 and were grouped according to Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE IⅡ) scores,patients with lower APACHE Ⅱ score (＜ 20) were divided into group A,otherwise they were included in group B.30 healthy individuals were served as control group.ELISA was utilized to detect the concentrations of IL-17 in peripheral blood of each group and relevant comparative analysis was applied to compare the differences between the groups.Results Level of peripheral IL-17 was significantly increased in patients with severe pneumonia compared with that of control group (P ＜ 0.05).Furthermore,expression of IL-17 increased more significantly in patients with higher APACHE Ⅱ score compared with the lower score group (P ＜ 0.05).Conclusion Patients with severe pneumonia have high expression of IL-17 and the degree of increase is related to the severity of the disease.This study suggests that IL-17 may play a crucial role in the onset and progress of severe pneumonia.