CAJ | 학술논문

目的比较帕利哌酮缓释片与奋乃静片治疗老年期精神分裂症的疗效和安全性.方法将63例老年期精神分裂症患者随机分为两组,分别予帕利哌酮缓释片和奋乃静片治疗8周,治疗前后采用阳性与阴性症状量表(PANSS)评定疗效、个人和社会功能量表(PSP)评定社会功能改善情况和副反应量表(TESS)观察不良反应.结果观察组和对照组总有效率分别为84.38％和80.65％,差异无统计学意义(P＞0.05).观察组不良反应低于对照组.结论帕利哌酮缓释片治疗老年精神分裂症疗效较好,安全性高,有利于长期巩固维持治疗.
목적 비교파리고동완석편여강내정편치료노년기정신분렬증적료효화안전성.방법 장63례노년기정신분렬증환자수궤분위량조,분별여파리고동완석편화강내정편치료8주,치료전후채용양성여음성증상량표(PANSS)평정료효、개인화사회공능량표(PSP)평정사회공능개선정황화부반응량표(TESS)관찰불량반응.결과 관찰조화대조조총유효솔분별위84.38％화80.65％,차이무통계학의의(P＞0.05).관찰조불량반응저우대조조.결론 파리고동완석편치료노년정신분렬증료효교호,안전성고,유리우장기공고유지치료.
Objective To investigate the efficacy and safety of paliperidone and perphenazine tablets in the treatment of eldedy schizophrenia.Methods A total of 63 elderly schizophrenia randomlized into two groups were respectively given Paliperidone or perphenazine for 8 weeks.Clinical effect was evaluated was Positive and Negative Symptom Scale (PANSS),Personal and Social Performance Scale (PSP) and the assessment of adverse drug reaction was evaluated with Traumatic Exposure Severity Scale (TESS).Results The total effective rate was respectively 84.38％ or 80.65％.There were no significant differences in the clinical effect between the two groups.And side effects of Paliperidone were less than perphenazine.Conclusion Paliperidone has good efficacy and high safety in the treatment of elderly schizophrenia patients.So it is beneficial to maintained treatment.