国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
23期
3599-3602
,共4页
2型糖尿病%高血压%氯沙坦钾片%氢氯噻嗪片%氯沙坦钾氢氯噻嗪片
2型糖尿病%高血壓%氯沙坦鉀片%氫氯噻嗪片%氯沙坦鉀氫氯噻嗪片
2형당뇨병%고혈압%록사탄갑편%경록새진편%록사탄갑경록새진편
Type 2 diabetic mellitus%Hypertension%Losartan potassium tablets%Hydrochlorothiazide tablets%Losartan potassium and hydrochlorothiazide tablets
目的 观察氯沙坦钾氢氯噻嗪片治疗2型糖尿病(Type 2Diabetes Mellitus,T2DM)合并高血压的临床效果及安全性.方法 将86例T2DM合并高血压患者按照数字表法随机分为两组,对照组采用氯沙坦钾片联合氢氯噻嗪片治疗;观察组则采用氯沙坦钾氢氯噻嗪片复合制剂治疗,并比较两组疗效.结果 观察组的总有效率(95.35％)明显高于对照组(81.40％)(P＜0.05),两组患者治疗前SBP、DBP相比较差异均无统计学意义(P＞0.05),两组患者治疗后SBP、DBP与治疗前比较差异有统计学意义(P＜0.05),观察组治疗后的SBP、DBP明显低于对照组(均P＜0.05),对照组患者治疗后FPG、P2hBG较前升高(P＜0.05),观察组患者治疗前后FPG、P2hBG无明显变化(P＞0.05);观察组治疗后FPG、P2hBG与对照组比较差异有统计学意义(均P＜0.05).结论 氯沙坦钾氢氯噻嗪片治疗T2DM合并高血压患者降压效果疗效肯定、起效快、作用强、安全性高、不良反应少,而且对血糖影响小,有利于提高患者服药依从性.
目的 觀察氯沙坦鉀氫氯噻嗪片治療2型糖尿病(Type 2Diabetes Mellitus,T2DM)閤併高血壓的臨床效果及安全性.方法 將86例T2DM閤併高血壓患者按照數字錶法隨機分為兩組,對照組採用氯沙坦鉀片聯閤氫氯噻嗪片治療;觀察組則採用氯沙坦鉀氫氯噻嗪片複閤製劑治療,併比較兩組療效.結果 觀察組的總有效率(95.35％)明顯高于對照組(81.40％)(P＜0.05),兩組患者治療前SBP、DBP相比較差異均無統計學意義(P＞0.05),兩組患者治療後SBP、DBP與治療前比較差異有統計學意義(P＜0.05),觀察組治療後的SBP、DBP明顯低于對照組(均P＜0.05),對照組患者治療後FPG、P2hBG較前升高(P＜0.05),觀察組患者治療前後FPG、P2hBG無明顯變化(P＞0.05);觀察組治療後FPG、P2hBG與對照組比較差異有統計學意義(均P＜0.05).結論 氯沙坦鉀氫氯噻嗪片治療T2DM閤併高血壓患者降壓效果療效肯定、起效快、作用彊、安全性高、不良反應少,而且對血糖影響小,有利于提高患者服藥依從性.
목적 관찰록사탄갑경록새진편치료2형당뇨병(Type 2Diabetes Mellitus,T2DM)합병고혈압적림상효과급안전성.방법 장86례T2DM합병고혈압환자안조수자표법수궤분위량조,대조조채용록사탄갑편연합경록새진편치료;관찰조칙채용록사탄갑경록새진편복합제제치료,병비교량조료효.결과 관찰조적총유효솔(95.35％)명현고우대조조(81.40％)(P＜0.05),량조환자치료전SBP、DBP상비교차이균무통계학의의(P＞0.05),량조환자치료후SBP、DBP여치료전비교차이유통계학의의(P＜0.05),관찰조치료후적SBP、DBP명현저우대조조(균P＜0.05),대조조환자치료후FPG、P2hBG교전승고(P＜0.05),관찰조환자치료전후FPG、P2hBG무명현변화(P＞0.05);관찰조치료후FPG、P2hBG여대조조비교차이유통계학의의(균P＜0.05).결론 록사탄갑경록새진편치료T2DM합병고혈압환자강압효과료효긍정、기효쾌、작용강、안전성고、불량반응소,이차대혈당영향소,유리우제고환자복약의종성.
Objective To observe the clinical curative effect and safety of losartan potassium and hydrochlorothiazide tablets on treating type 2 diabetic mellitus with hypertension.Methods 86 patients with type 2 diabetic mellitus and hypertension were divided into the test group and the control group with the method of randomized controlled trials according to randomized controlled table.The control group was treated with losartan potassium tablets and hydrochlorothiazide tablets.The test group was treated with losartan potassium and hydrochlorothiazide tablets.Finally,the clinical curative effects were compared.Results In the total efficiency,the test group was 95.35％,the control group was 81.40％,the test group was significantly better than the control group (P ＜ 0.05).Systolic blood pressure and diastolic blood pressure before treatment had no statistical significant difference (P ＞ 0.05).Systolic blood pressure and diastolic blood pressure after treatment of the two group was lower than that before treatment (P ＜ 0.05).Systolic blood pressure and diastolic blood pressure of the test group was lower than that of the control group (P ＜ 0.05),FPG and P2hBG after treatment of the control group increased,the other groups had no significant changes.The test group was better than the control group (P ＜ 0.05).Conclusion Losartan potassium and hydrochlorothiazide tablets on treating type 2 diabetic mellitus with hypertension has efficient,fast and strong curative effect,with higher safety and less adverse reactions.Losartan potassium and hydrochlorothiazide tablets has less influence on blood glucose.It can improve patients' drug therapy compliance.
