国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2014年
6期
363-367
,共5页
汤敏敏%刘建中%武志芳%陆克义%李思进%高永举%武新宇%徐俊玲
湯敏敏%劉建中%武誌芳%陸剋義%李思進%高永舉%武新宇%徐俊玲
탕민민%류건중%무지방%륙극의%리사진%고영거%무신우%서준령
甲状腺肿瘤%碘放射性同位素%体层摄影术,发射型计算机,单光子
甲狀腺腫瘤%碘放射性同位素%體層攝影術,髮射型計算機,單光子
갑상선종류%전방사성동위소%체층섭영술,발사형계산궤,단광자
Thyroid neoplasms%Iodine radioisotopes%Tomography,emission-computed,single-photon
目的 评估分化型甲状腺癌(DTC)患者131I治疗后体内残留放射性活度.方法 本研究共纳入了35例DTC患者,分为“清甲”(20例)与“清灶”(15例)组,分别于服13I后2、6、24、48、72 h进行131I全身显像及1m处当量剂量率的测定,以2h时显像计数和活度作为总计数和总活度.根据各时间点显像计数与2h的显像计数比值间接估算体内残留放射性活度,并估算患者体内残留放射性活度达到400 MBq时的1m处当量剂量率.统计学分析采用直线相关与回归分析.结果 “清甲”组服131I后2、6、24、48、72 h体内残留131I活度占服131I总活度的百分比分别为99％±4％、86％±6％、35％±10％、12％±8％、7％±8％, “清灶”组分别为99％±1％、91％±7％、47％±17％、11％±9％、4％±6％. “清甲”组服131I后2、6、24、48、72 h的1m处当量剂量率分别为(157±37)、(120±36)、(35±13)、(11±9)、(9±11)μSv/h,“清灶”组分别为(234±43)、(186±51)、(49±20)、(12±11)、(4±6)μSv/h.体内残留的放射性活度与1m处当量剂量率呈正相关(r=0.87,P＜0.001).“清甲”与“清灶”组服131I后48、72 h体内残留放射性活度分别为(432±292)、(265±281) MBq及(731±701)、(277±470) MBq,对应的1m处当量剂量率为8～ 11 μSv/h.结论 DTC患者服131I后48～72 h体内残留放射性活度达到国家标准规定的400 MBq时,即DTC患者1m处当量剂量率达到8～11 μSv/h时方可出院.
目的 評估分化型甲狀腺癌(DTC)患者131I治療後體內殘留放射性活度.方法 本研究共納入瞭35例DTC患者,分為“清甲”(20例)與“清竈”(15例)組,分彆于服13I後2、6、24、48、72 h進行131I全身顯像及1m處噹量劑量率的測定,以2h時顯像計數和活度作為總計數和總活度.根據各時間點顯像計數與2h的顯像計數比值間接估算體內殘留放射性活度,併估算患者體內殘留放射性活度達到400 MBq時的1m處噹量劑量率.統計學分析採用直線相關與迴歸分析.結果 “清甲”組服131I後2、6、24、48、72 h體內殘留131I活度佔服131I總活度的百分比分彆為99％±4％、86％±6％、35％±10％、12％±8％、7％±8％, “清竈”組分彆為99％±1％、91％±7％、47％±17％、11％±9％、4％±6％. “清甲”組服131I後2、6、24、48、72 h的1m處噹量劑量率分彆為(157±37)、(120±36)、(35±13)、(11±9)、(9±11)μSv/h,“清竈”組分彆為(234±43)、(186±51)、(49±20)、(12±11)、(4±6)μSv/h.體內殘留的放射性活度與1m處噹量劑量率呈正相關(r=0.87,P＜0.001).“清甲”與“清竈”組服131I後48、72 h體內殘留放射性活度分彆為(432±292)、(265±281) MBq及(731±701)、(277±470) MBq,對應的1m處噹量劑量率為8～ 11 μSv/h.結論 DTC患者服131I後48～72 h體內殘留放射性活度達到國傢標準規定的400 MBq時,即DTC患者1m處噹量劑量率達到8～11 μSv/h時方可齣院.
목적 평고분화형갑상선암(DTC)환자131I치료후체내잔류방사성활도.방법 본연구공납입료35례DTC환자,분위“청갑”(20례)여“청조”(15례)조,분별우복13I후2、6、24、48、72 h진행131I전신현상급1m처당량제량솔적측정,이2h시현상계수화활도작위총계수화총활도.근거각시간점현상계수여2h적현상계수비치간접고산체내잔류방사성활도,병고산환자체내잔류방사성활도체도400 MBq시적1m처당량제량솔.통계학분석채용직선상관여회귀분석.결과 “청갑”조복131I후2、6、24、48、72 h체내잔류131I활도점복131I총활도적백분비분별위99％±4％、86％±6％、35％±10％、12％±8％、7％±8％, “청조”조분별위99％±1％、91％±7％、47％±17％、11％±9％、4％±6％. “청갑”조복131I후2、6、24、48、72 h적1m처당량제량솔분별위(157±37)、(120±36)、(35±13)、(11±9)、(9±11)μSv/h,“청조”조분별위(234±43)、(186±51)、(49±20)、(12±11)、(4±6)μSv/h.체내잔류적방사성활도여1m처당량제량솔정정상관(r=0.87,P＜0.001).“청갑”여“청조”조복131I후48、72 h체내잔류방사성활도분별위(432±292)、(265±281) MBq급(731±701)、(277±470) MBq,대응적1m처당량제량솔위8～ 11 μSv/h.결론 DTC환자복131I후48～72 h체내잔류방사성활도체도국가표준규정적400 MBq시,즉DTC환자1m처당량제량솔체도8～11 μSv/h시방가출원.
Objective To estimate the residual activities of patients with differentiated thyroid cancer(DTC) after administration of 131I for post-operative therapy.Methods Thirty-five DTC patients were divided into thyroid remnant 131I ablation therapy group (20 cases)and 131I treatment for metastatic lesions group (15 cases).131I whole body scan and the determination of equivalent dose rate at 1 meter point were performed to estimate multi-temporal residual activities in each patient 2,6,24,48,and 72 h after administration of therapeutic doses of 131I,respectively.The percentage of residual activities was indirectly estimated in vivo through ratio of multi-temporal calculation of radioactive counts on 131I whole body imaging versus that at 2 h(radioactive counts on 131I whole body imaging and 131I activity at 2 h were regarded as total counts and activities),and furthermore the equivalent dose rate at 1 meter point was indirectly estimated when the residual activities reach to 400 MBq.Correlation and regression analysis were used to evaluate the relationship between residual activities and the equivalent dose rate at 1 m.Statistical significance was accepted at P＜0.05.Results The percentage of residual activities were 99％±4％,86％±6％,35％± 10％,12％±8％,7％±8％ in thyroid remnant 131I ablation therapy group,and 99％±1％,91％±7％,47％± 17％,11％±9％ and 4％±6％ in 131I treatment for metastatic lesions group at 2,6,24,48 and 72 h after administration of 131I,respectively.The equivalent dose rates at 1 m point were (157±37),(120±36),(35±13),(11±9) and (9±11) μSv/h in thyroid remnant 131I ablation therapy group and (234±43),(186±51),(49±20),(12±11) and (4±6) μSv/h in 131I treatment for metastatic lesions group at 2,6,24,48 and 72 h after administration of 131I,respectively.There is a positive correlation between residual activities and equivalent dose rate at 1 m(r=0.87,P＜0.001).The residual activities were(432±292),(265± 281) MBq 48 and 72 h after administration of 131I in thyroid remnant 131I ablation therapy group and (731±701),(277±470) MBq in 131I treatment for metastatic lesions group.At the same point of time,the corresponding range of equivalent dose rate at 1 m was from 8 to 11 μSv/h.Conclusion The in vivo residual activity reaches the national standard of 400 MBq in patients with differentiated thyroid cancer 48～72 h after serving 131I and the range of equivalent dose rate at 1 m was from 8 to 11 μSv/h.At this time,radiation isolation could be discharged.
