CAJ | 학술논문

背景在肝脏移植术及肝脏切除等相关手术中,肝脏缺血/再灌注损伤(ischemia/reperfusion injury,I/RI)影响手术的成败、术后患者肝脏功能的恢复、患者生存率及生存质量.很多相关的实验研究I/RI的发生发展机制、寻求解决或缓解该损伤的有效干预措施. 目的综述国内外缺血预处理(ischemic preconditioning,IPC)在肝脏手术中的实验研究与临床应用,为预防肝脏I/RI提供临床新思维. 内容就近5年关于肝脏IPC及远端缺血预处理(remote ischemic preconditioning,RIPC)对肝脏I/RI的保护作用进行阐述. 趋向随着对肝脏IPC机制及临床应用的不断研究,将对其今后的发展提供更全面的依据.
배경 재간장이식술급간장절제등상관수술중,간장결혈/재관주손상(ischemia/reperfusion injury,I/RI)영향수술적성패、술후환자간장공능적회복、환자생존솔급생존질량.흔다상관적실험연구I/RI적발생발전궤제、심구해결혹완해해손상적유효간예조시. 목적 종술국내외결혈예처리(ischemic preconditioning,IPC)재간장수술중적실험연구여림상응용,위예방간장I/RI제공림상신사유. 내용 취근5년관우간장IPC급원단결혈예처리(remote ischemic preconditioning,RIPC)대간장I/RI적보호작용진행천술. 추향 수착대간장IPC궤제급림상응용적불단연구,장대기금후적발전제공경전면적의거.
Background Ischemia/reperfusion injury (I/RI) plays an important role in many liver surgeries,such as liver transplantation and hepatectomy.Much work has been done investigating the mechanism of I/RI and the therapies to alleviate the I/RI.Objective This review aims to provide new insights into preventing hepatic I/RI by summarizing the research actuality involved in hepatic ischemic preconditioning (IPC).Content We reviewed the two protective methods including IPC and remote ischemic preconditioning (RIPC) investigated in the latest five years.Trend The protective mechanism of ischemic preconditioning in liver should be deeply clarified to provide enough proof for clinical application.