CAJ | 학술논문

背景适度的炎症反应是机体的一种保护性防御机制,而炎症反应失控会导致组织损伤.多不饱和脂肪酸衍生的脂类介质消退素具有抗炎症、促进炎症消退的功能,对肺部炎症性疾病,如急性肺损伤、哮喘、慢性阻塞性肺病等均有保护作用. 目的通过总结近些年研究消退素在肺部炎性疾病中的作用,为其进一步研究奠定基础. 内容介绍消退素的生成、分类及分子结构,总结消退素减轻肺部炎症的可能分子机制. 趋向随着对消退素研究的深入,消退分子可能成为治疗肺部炎症性疾病的一种新型药物.
배경 괄도적염증반응시궤체적일충보호성방어궤제,이염증반응실공회도치조직손상.다불포화지방산연생적지류개질소퇴소구유항염증、촉진염증소퇴적공능,대폐부염증성질병,여급성폐손상、효천、만성조새성폐병등균유보호작용. 목적 통과총결근사년연구소퇴소재폐부염성질병중적작용,위기진일보연구전정기출. 내용 개소소퇴소적생성、분류급분자결구,총결소퇴소감경폐부염증적가능분자궤제. 추향 수착대소퇴소연구적심입,소퇴분자가능성위치료폐부염증성질병적일충신형약물.
Background Moderate inflammatory response is a kind of protective defense mechanism,however,uncontrolled inflammation may give rise to tissue damage.Resolvin,a kind of polyunsaturated fatty acid-derived lipid mediators,exhibit anti-inflammatory and pro-resolving functions,which can alleviate pulmonary inflammatiory diseases,such as acute lung injury,asthma,chronic obstructive pulmonary disease.Objective This review lay the foundations for the research of Resolvin in pulmonary inflammatory diseases.Content This review describes the production,classification and molecular structure of Resolvin.In addition,we summarize the mechanisms of Resolvin in reducing pulmonary inflammatory diseases.Trend With the development in resolvin research,it's possible that pro-resolving mediators be a new drug in the treatment of pulmonary inflammatory diseases.