CAJ | 학술논문

背景抵抗素样分子-α(resistin-like molecule alpha,RELM-α)又称为FIZZ1 (found ininflammatory zone 1),是近年来新发现的分泌型细胞因子.研究表明RELM-α具有多种生理作用,参与许多疾病的发生发展过程. 目的通过综述的方式对RELM-α的生理作用和机制进行系统的阐述,为以后的研究提供参考,引导新的研究领域. 内容基于目前RELM-α的研究进展,一方面总结了RELM-α具有多种生理功能,另一方面阐述了RELM-α的作用机制. 趋向 RELM-α已得到越来越多的学者关注,目前关于RELM-α与肺相关疾病研究较多,其在其他疾病中发挥的作用及作用机制研究较少,具有广阔的研究前景.
배경 저항소양분자-α(resistin-like molecule alpha,RELM-α)우칭위FIZZ1 (found ininflammatory zone 1),시근년래신발현적분비형세포인자.연구표명RELM-α구유다충생리작용,삼여허다질병적발생발전과정. 목적 통과종술적방식대RELM-α적생리작용화궤제진행계통적천술,위이후적연구제공삼고,인도신적연구영역. 내용 기우목전RELM-α적연구진전,일방면총결료RELM-α구유다충생리공능,령일방면천술료RELM-α적작용궤제. 추향 RELM-α이득도월래월다적학자관주,목전관우RELM-α여폐상관질병연구교다,기재기타질병중발휘적작용급작용궤제연구교소,구유엄활적연구전경.
Background Resistin-like molecule-α (RELM-α) known as found in inflammatory zone 1 (FIZZ1) has been found to be a new type of secretory cytokine in recent years.The studies have showed that RELM-α has many physiological functions and is involved in development of many diseases.Objective To review the physiological actions and mechanism of RELM-α to provide a reference for further research and to inspire new research fields.Content This article is based on the current research progress.RELM-α was summarized mainly from two aspects:the various physiological functions and its mechanism of action.Trend RELM-α has raised more and more researchers' concerns.More studies focus on RELM-α related pulmonary diseases,but less on its roles in other diseases and mechanism of action.So it has a wide research prospect.