国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2014年
11期
750-754
,共5页
闫磊磊%姚敬%严雪冰%汪昱
閆磊磊%姚敬%嚴雪冰%汪昱
염뢰뢰%요경%엄설빙%왕욱
骨膜蛋白%上皮-间质转化%结直肠肿瘤%钙粘着蛋白类%组织
骨膜蛋白%上皮-間質轉化%結直腸腫瘤%鈣粘著蛋白類%組織
골막단백%상피-간질전화%결직장종류%개점착단백류%조직
Periostin%Epithelial-mesenchymal transition%Colorectal neoplasms%Cadherins%Tissues
目的 探讨结直肠癌中骨膜蛋白与上皮间质转化标志物E-cadherin、N-cadherin和临床病理参数间的相关性.方法 通过免疫组织化学染色方法检测106例结直肠癌患者癌组织和对应癌旁正常组织中骨膜蛋白、E-cadherin和N-cadherin表达情况,并对其结果进行分析.结果 骨膜蛋白、E-cadherin和N-cadherin在结直肠癌组织中表达与对应癌旁正常组织相比差异有统计学意义(62/106 vs 21/106,x2=34.027,P＜0.05;43/106 vs 89/106,x2 =42.480,P＜0.05;66/106 vs 19/106,x2 =43.382,P＜0.05).结直肠癌组织中骨膜蛋白表达水平与肿瘤分化程度、肿瘤浸润程度、淋巴结转移及远处转移有关(x2=7.752,P =0.007; x2 =5.008,P=0.031; x2=10.227,P =0.002; x2 =8.001,P=0.006),与E-cadherin表达呈负相关(r=-0.435,P＜0.001),与N-cadherin表达呈正相关(r=0.213,P=0.028).结论 骨膜蛋白可能通过调节上皮间质转化过程参与结直肠癌的发生发展.
目的 探討結直腸癌中骨膜蛋白與上皮間質轉化標誌物E-cadherin、N-cadherin和臨床病理參數間的相關性.方法 通過免疫組織化學染色方法檢測106例結直腸癌患者癌組織和對應癌徬正常組織中骨膜蛋白、E-cadherin和N-cadherin錶達情況,併對其結果進行分析.結果 骨膜蛋白、E-cadherin和N-cadherin在結直腸癌組織中錶達與對應癌徬正常組織相比差異有統計學意義(62/106 vs 21/106,x2=34.027,P＜0.05;43/106 vs 89/106,x2 =42.480,P＜0.05;66/106 vs 19/106,x2 =43.382,P＜0.05).結直腸癌組織中骨膜蛋白錶達水平與腫瘤分化程度、腫瘤浸潤程度、淋巴結轉移及遠處轉移有關(x2=7.752,P =0.007; x2 =5.008,P=0.031; x2=10.227,P =0.002; x2 =8.001,P=0.006),與E-cadherin錶達呈負相關(r=-0.435,P＜0.001),與N-cadherin錶達呈正相關(r=0.213,P=0.028).結論 骨膜蛋白可能通過調節上皮間質轉化過程參與結直腸癌的髮生髮展.
목적 탐토결직장암중골막단백여상피간질전화표지물E-cadherin、N-cadherin화림상병리삼수간적상관성.방법 통과면역조직화학염색방법검측106례결직장암환자암조직화대응암방정상조직중골막단백、E-cadherin화N-cadherin표체정황,병대기결과진행분석.결과 골막단백、E-cadherin화N-cadherin재결직장암조직중표체여대응암방정상조직상비차이유통계학의의(62/106 vs 21/106,x2=34.027,P＜0.05;43/106 vs 89/106,x2 =42.480,P＜0.05;66/106 vs 19/106,x2 =43.382,P＜0.05).결직장암조직중골막단백표체수평여종류분화정도、종류침윤정도、림파결전이급원처전이유관(x2=7.752,P =0.007; x2 =5.008,P=0.031; x2=10.227,P =0.002; x2 =8.001,P=0.006),여E-cadherin표체정부상관(r=-0.435,P＜0.001),여N-cadherin표체정정상관(r=0.213,P=0.028).결론 골막단백가능통과조절상피간질전화과정삼여결직장암적발생발전.
Objective To investigate the correlation between the Periostin and Epithelial-Mesenchymal Transition(EMT) markers(E-cadheirn and N-cadheirn) in colorectal cancer(CRC),and analyze the relationship between the expression of Periostin and clinicopathological parameters.Methods The expression of Periostin,Ecadheirn and N-cadheirn in 106 cases with primary CRC tumors and corresponding normal tissues were detected by Immunohistoehemistry and the results were analyzed.Results The expression of Periostin,E-cadheirn and N-cad-heirn in tumors were significantly high expression than those in corresponding normal tissues(62/106 vs 21/106,x2 =34.027,P ＜ 0.05 ;43/106 vs 89/106,x2 =42.480,P ＜ 0.05 ; 66/106 vs 19/106,x2 =43.382,P ＜ 0.05).The expression of Periostin in tumors was associated significantly with tumor differentiation,tumor invasion,lymph node metastasis and distance metastasis (x2 =7.752,P =0.007; x2 =5.008,P =0.031 ; x2 =10.227,P =0.002;x2 =8.001,P =0.006).It was negatively correlated with E-cadherin expression (r =-0.435,P ＜ 0.001),but positively correlated with N-cadherin expression (r =0.213,P =0.028).Conclusion Periostin may promote the occurrence and development of CRC by participating in EMT program.
