CAJ | 학술논문

神经胶质瘤作为最常见高发病率和病死率的原发性脑肿瘤,是成人和儿童死亡的一个重要原因.目前通过手术切除辅助放疗和化疗治疗神经胶质瘤预后不佳,胶质细胞瘤患者自确诊后中位生存期很短.神经胶质瘤的发病过程中,microRNA-21(miR-21)调节胶质瘤细胞相关分子的表达,影响下游信号通路从而耐受胶质瘤的放化疗.本文就miR-21与神经胶质瘤发病相关性,及神经胶质瘤放化疗研究进展进行综述.
신경효질류작위최상견고발병솔화병사솔적원발성뇌종류,시성인화인동사망적일개중요원인.목전통과수술절제보조방료화화료치료신경효질류예후불가,효질세포류환자자학진후중위생존기흔단.신경효질류적발병과정중,microRNA-21(miR-21)조절효질류세포상관분자적표체,영향하유신호통로종이내수효질류적방화료.본문취miR-21여신경효질류발병상관성,급신경효질류방화료연구진전진행종술.
Glioma is an important cause of death in adults and children among the most common neural malignancies,with high morbidity and mortality in primary brain tumors.Despite advances in radiation and chemotherapy following surgical resection of the tumor,the median survival time of glioma remains poor.The effects of miR-21expression on tumor growth and invasion via regulating the pathways in human glioma cells,which regulate the expression of some small molecule.This review is mainly focused on the discovery of the correlation between microRNA-21 (miR-21) and glioma and the important role in the resistance of cancer cells to radiation and chemotherapeutic agents.