CAJ | 학술논문

去整合素-金属蛋白酶(ADAM)17是ADAM超家族中的重要一员,可介导多种膜分子水解脱落,如黏附因子、细胞因子、生长因子等.通过EGFR-PI3K-Akt途径、Notch传导通路等信号途径,ADAM17在调节肿瘤细胞的黏附、凋亡、转移、增殖等过程中发挥重要作用.ADAM17靶向药物的研究为肿瘤治疗提供了新方向.
거정합소-금속단백매(ADAM)17시ADAM초가족중적중요일원,가개도다충막분자수해탈락,여점부인자、세포인자、생장인자등.통과EGFR-PI3K-Akt도경、Notch전도통로등신호도경,ADAM17재조절종류세포적점부、조망、전이、증식등과정중발휘중요작용.ADAM17파향약물적연구위종류치료제공료신방향.
As an important member of the adisintegrin and metalloproteinase (ADAM) superfamily,ADAM17 can mediate a variety of membrane molecular hydrolysis off,such as adhesion molecules,cytokines,growth factors,etc,and play an important role in regulating tumor cell adhesion,apoptosis,metastasis and proliferation through the EGFR-PI3K-Akt pathway,Notch signaling pathway and other signaling pathways.The research of ADAM17 targeted drugs provides a new direction for cancer therapy.