CAJ | 학술논문

DNA聚合酶iota(Pol)与DNA修复基因Rev1、DNA聚合酶kappa (Polκ)、DNA聚合酶eta(Polη)同为Y家族聚合酶,能通过跨损伤修复对损伤DNA进行修复.但是在所有的DNA聚合酶中,Pol(t)具有最低的保真性,在错误和正确模板的情况下都有很高的错配几率,且能够跨过一些DNA损伤将错配累积起来.最近研究表明Pol(t)在一些肿瘤组织中表达异常,包括人葡萄膜黑色素瘤、乳腺癌、膀胱癌、肺癌和食管癌.异常表达的Pol(t)与肿瘤发生发展关系密切,其修复DNA损伤的功能可能与肿瘤的放化疗抵抗相关.
DNA취합매iota(Pol)여DNA수복기인Rev1、DNA취합매kappa (Polκ)、DNA취합매eta(Polη)동위Y가족취합매,능통과과손상수복대손상DNA진행수복.단시재소유적DNA취합매중,Pol(t)구유최저적보진성,재착오화정학모판적정황하도유흔고적착배궤솔,차능구과과일사DNA손상장착배루적기래.최근연구표명Pol(t)재일사종류조직중표체이상,포괄인포도막흑색소류、유선암、방광암、폐암화식관암.이상표체적Pol(t)여종류발생발전관계밀절,기수복DNA손상적공능가능여종류적방화료저항상관.
DNA polymerase iota (Polt),as well as Revl,Polκ and Polη,are all Y family DNA polymerases,which are able to replicate damaged DNA via translesion synthesis pathway.However,Pol(t) has the lowest fidelity among all DNA polymerases in both correct and inaccurate DNA templates.Also Pol(t) can bypass certain DNA damages and accumulate mutations.Recent studies show that the aberrant expression of Pol(t) is observed in human uveal melanoma,breast cancer,bladder cancer,lung cancer and esophageal cancer,which may contribute to the tumorigenesis and progression of tumor.The special role of Pol(t) in replicating damaged DNA may contribute to the resistance in oncotherapy.