CAJ | 학술논문

雷帕霉素靶蛋白(mTOR)信号通路与肿瘤细胞的增殖、周期调控等多种病理过程密切相关.雷帕霉素通过抑制mTOR起到抗肿瘤作用,但其容易产生耐药等缺点导致临床应用受限,耐药机制主要与mTOR受抑后负反馈激活磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)有关.mTOR通路相关蛋白的双重抑制剂等药物有望逆转其耐药.
뢰파매소파단백(mTOR)신호통로여종류세포적증식、주기조공등다충병리과정밀절상관.뢰파매소통과억제mTOR기도항종류작용,단기용역산생내약등결점도치림상응용수한,내약궤제주요여mTOR수억후부반궤격활린지선기순3-격매-단백격매B(PI3K-Akt)유관.mTOR통로상관단백적쌍중억제제등약물유망역전기내약.
mTOR signaling pathway is closely related to cell proliferation,cell cycle and other pathological processes about tumor.Rapamycin plays an anti-tumor effect through inhibiting mTOR,but it prone to drug resistance,which leads to limited clinical application.Its resistant mechanism is related with the activation of PI3K-Akt,which is regulated with negative feedback.Dual inhibitors of related proteins of mTOR pathway are expected to reverse the drug resistance.