CAJ | 학술논문

放疗抵抗是导致临床放疗失败及影响患者病情进展的主要原因.放疗抵抗的发生与细胞周期阻滞、相关基因改变、肿瘤微环境变化、自噬性调节及肿瘤干细胞的存在等多种因素相关.研究放疗抵抗机制,并寻找有效应对措施以减少放疗抵抗是提高放疗疗效的关键,同时也将为肿瘤放疗敏感性的预测提供可能.
방료저항시도치림상방료실패급영향환자병정진전적주요원인.방료저항적발생여세포주기조체、상관기인개변、종류미배경변화、자서성조절급종류간세포적존재등다충인소상관.연구방료저항궤제,병심조유효응대조시이감소방료저항시제고방료료효적관건,동시야장위종류방료민감성적예측제공가능.
Tumor radioresistance is the leading cause of clinical radiotherapy failure and disease progression.Researches show that the occurrence of radioresistance is related to the cell cycle arrest,relevant gene change,tumor microenvironment change,autophagy,tumor stem cells and other factors.Studying the mechanism of radioresistance and looking for an effective method to avoid it is the key to improve the effect of radiotherapy,which can provide the probability of the prognosis of radiosensitivity.